Well Known Cancer Protocols

Evidence-backed protocols, mechanisms, and custom reports.

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Disclaimer: This page is for informational purposes only and does not constitute medical advice. These protocols are experimental, based largely on anecdotal or early-stage evidence, and are not FDA-approved for cancer treatment. Drug interactions and toxicities are possible. Consult a qualified clinician before starting or modifying any therapy.
Joe Tippens Protocol
Microtubules ↓ NF-ΞΊB ↓ STAT3 ↓ COX-2 ↓ TRPV1 / PPAR-Ξ³ ↑ Anti-angiogenesis

Core Components & Dosing

  • Fenbendazole 222 mg (Panacur C) β€” 3 days ON / 4 days OFF
  • Curcumin 600 mg/day (high-bioavailability)
  • Vitamin E (Ξ³-tocopherol) 400–800 IU/day
  • CBD Oil 25 mg/day
  • Add-ons: Quercetin | Berberine | Milk Thistle

Mechanistic Rationale

  • Fenbendazole β†’ microtubule destabilisation  β†’  mitotic arrest
  • Curcumin / Ξ³-tocopherol β†’ NF-ΞΊB, STAT3, COX-2 inhibition
  • CBD β†’ TRPV1 & PPAR-Ξ³ activation, anti-angiogenesis

Evidence Snapshot

  • Case reports & in-vitro / animal data; no RCTs
  • Protocol publicised after Joe Tippens’ SCLC remission (2017)

Cycle / Monitoring

  • Continuous; imaging q8–12 weeks
  • Liver panel & CBC q4–6 weeks

Key Cautions

  • Mild hepatotoxicity possible; rare neutropenia
  • High-dose Ξ³-tocopherol may thin blood β€” monitor with anticoagulants
Dr. William Makis Protocol
WNT/Ξ²-catenin ↓ Microtubules ↓ P-gp ↓ GLUT-1 ↓ Glutamine block Mitochondrial collapse

Ivermectin Tiers

  • Low-grade 0.5 mg/kg Β· 3Γ— week
  • Intermediate 1 mg/kg Β· 3Γ— week
  • High-grade 1–2 mg/kg daily
  • Very aggressive ≀ 2.5 mg/kg daily

Benzimidazoles & DON

  • Mebendazole 200β†’400β†’1500 mg/day (grade-based)
  • Fenbendazole 1000 mg, 3Γ— week (high-grade)
  • DON 0.2–0.6 mg/kg IV/IM or ≀ 1.1 mg/kg oral daily

Supportive Stack

  • IV Vitamin C 1.5 g/kg Β· 2–3Γ— week
  • Vitamin D3 25–50 k IU/day (load) β†’ 2 k IU/day (maint)
  • Zinc 1 mg/kg/day β†’ 5 mg/day maintenance
  • Strict keto (< 20 g carbs) + 3–7-day water fasts q3–4 weeks
  • HBOT 1.5–2.5 ATA Β· 90 min Β· 2–3Γ— week

Mechanistic Highlights

  • Ivermectin β†’ WNT/TCF inhibition, mitochondrial collapse, P-gp block
  • Mebendazole/Fenbendazole β†’ microtubule disruption; GLUT-1 down-reg
  • DON β†’ glutamine antagonist, starves TCA cycle

Cycle / Monitoring

  • Typical length β‰ˆ 12 weeks, then imaging & labs
  • Labs: CBC, CMP, vitamin D, ferritin, insulin, ketones, uric acid

Key Cautions

  • High-dose IVM β†’ CNS effects if BBB compromised
  • LFTs with benzimidazoles; electrolyte shifts during fasting
Jane McLelland β€œMetro Map” Protocol
Glycolysis ↓ Glutamine ↓ FAO ↓ Mitochondria ↓ mTOR ↓ NF-ΞΊB ↓

Fuel-Blocking Drug Blocks

  • Glucose block – Berberine 500 mg TID, Metformin 500 mg BID
  • Glutamine block – Dipyridamole 75–100 mg, Aspirin 75–150 mg
  • Fatty-acid block – Hydroxycitrate 500 mg TID, Statin 40 mg
  • Mito-block – Doxycycline 100 mg BID + Artemisinin/Niclosamide pulse

Rationale

  • Starves multiple metabolic routes simultaneously
  • Rotating / layering mimics multi-agent chemo with lower toxicity

Evidence & Monitoring

  • Case-series show durable responses in late-stage patients
  • Labs monthly; imaging q12 weeks

Key Cautions

  • Poly-pharmacy interaction risk (e.g., statin + azoles β†’ rhabdo)
  • Aspirin/Dipyridamole ↑ bleeding β€” avoid peri-surgery
Care Oncology Clinic Quad
AMPK ↑ mTOR ↓ Mevalonate ↓ Mito-biogenesis ↓ Microtubules ↓

Standard Drug Quad

  • Metformin XR 500–1000 mg BID – AMPK ↑ / mTOR ↓
  • Atorvastatin 40 mg qHS – Mevalonate pathway ↓
  • Doxycycline 100 mg QD–BID – Mitochondrial biogenesis ↓
  • Mebendazole 100 mg QD (or 500 mg 3Γ—/wk) – Microtubule disruptor

Clinical Evidence

  • UK registry (> 2000 pts) shows OS signal in GBM, TNBC, prostate
  • Prospective RCT underway for NSCLC + chemo-IO

Monitoring & Cautions

  • Liver panel & CK baseline + q12 weeks
  • Statin myalgias & Metformin GI upset common
Dr. Valter Longo – Fasting-Mimicking Diet
IGF-1 ↓ mTOR ↓ Autophagy ↑ Ketogenesis ↑ Stem-cell reset

Protocol Summary

  • 5-day plant-based kit: Day 1 β‰ˆ 1100 kcal; Days 2-5 β‰ˆ 750 kcal
  • Macros: 10% protein | 45% fat | 45% complex carbs
  • Cycle monthly or before chemo cycles

Mechanism

  • Reduces IGF-1, mTOR, glucose β†’ stresses tumour cells
  • Re-feeding triggers hematopoietic regeneration

Data

  • Mouse: FMD + chemo doubles survival vs chemo alone
  • Phase II trials (breast, prostate) show ↑ QoL & ↓ toxicity

Cautions

  • Not for cachectic or BMI < 19 without supervision
Dr. Thomas Seyfried – Press-Pulse Metabolic Therapy
Ketosis ↑ Glycolysis ↓ mTOR ↓ Mito-stress ROS modulation

Core Elements

  • Ketogenic 4:1 diet, calories –20 - 30 % below BMR
  • Pulse: 2-DG, HBOT, or exogenous ketones 2–3Γ— week
  • Target GKI ≀ 2.0 via daily finger-stick

Supporting Evidence

  • Pre-clinical GBM: 80 % tumour volume reduction
  • Case reports: multi-year NED in ND-GBM & Stage IV lung

Cautions

  • Ketoacidosis risk in uncontrolled diabetics; monitor electrolytes
Dr. Nicholas Gonzalez Enzyme Protocol
Proteolysis ↑ Detox ↑ Immune ↑

Daily Schedule

  • 130–175 pancreatic enzyme caps / day (6–8 doses)
  • 13 fresh vegetable juices, organic diet
  • 2–4 coffee enemas daily + liver flushes

Evidence

  • NIH pilot in pancreatic Ca: median OS 17.5 mo vs 4 mo historical
  • Randomised trial halted early; inconclusive

Cautions

  • High pill burden; risk of steatorrhea & electrolyte imbalance
Dr. Raymond Chang Integrative (AMRF) Protocol
COX-2 ↓ Angiogenesis ↓ NF-ΞΊB ↓ Mito-block Immune ↑

Typical Cocktail

  • Repurposed Rx: Metformin, Celecoxib, Cimetidine, Doxycycline
  • Botanicals: Artemisinin 600 mg pulse, Scutellaria 1 g, Curcumin 3 g
  • Immune mod: Low-dose IL-2, Mistletoe, Ξ²-glucans

Rationale & Data

  • Multi-target inhibition of angiogenesis, inflammation, stem-cell renewal
  • NYC clinic cohort shows OS extension in metastatic sarcoma & CRC

Cautions

  • Cimetidine inhibits CYP450 β†’ ↑ many drug levels
Rick Simpson Oil (RSO)
CB1/CB2 ↑ Apoptosis ↑ Autophagy ↑ Anti-angiogenesis

Dosing Ramp

  • Start 0.1 g/day, doubling every 4 days β†’ 1 g/day
  • Maintain 1 g/day for 60–90 days (~ 60 g course)

Mechanism

  • High THC binds CB1/CB2 β†’ apoptosis, autophagy, anti-angiogenesis

Cautions

  • Psychoactive; do not drive
  • Legal status varies; ensure solvent-free product
Budwig Protocol
Omega-3 ↑ Mito function ↑ Anti-inflammation

Daily Steps

  • Blend 2 tbsp flaxseed oil + Β½ cup cottage cheese + berries
  • Pescatarian whole-food diet, no refined oils/sugar
  • 15 min sun exposure for vitamin D

Rationale

  • Linolenic acid + sulfur proteins improve electron transport

Cautions

  • PUFA oxidation if oil not fresh; monitor triglycerides
Gerson Therapy
Detox ↑ Antioxidants ↑ Immune ↑

Core Elements

  • 13 Γ— 8 oz organic juices daily (hourly)
  • Up to 5 coffee enemas to boost glutathione-S-transferase
  • Supplements: potassium, Lugol’s iodine, pancreatin, B12

Evidence

  • Historical case series; controlled data lacking

Cautions

  • Risk of hyponatremia & hypocalcemia; needs medical oversight
Insulin-Potentiation Therapy (IPT)
Chemo sensitiser Insulin receptor ↑ Toxicity ↓

Procedure

  • IV insulin β†’ blood glucose β‰ˆ 40 mg/dL
  • Low-dose chemo (10–15 % standard) at nadir
  • Dextrose rescue + nutrients

Rationale

  • Cancer cells overexpress insulin receptors β†’ absorb more chemo
  • Aims to keep efficacy while reducing systemic toxicity

Cautions

  • Severe hypoglycaemia risk; must be done by experienced team
  • Lack of large-scale trials; regulatory acceptance limited
Final Reminder: None of these protocols replace evidence-based oncology care. Always share alternative plans with your oncologist to manage interactions, imaging, and lab monitoring.