Well Known Cancer Protocols

Evidence-backed protocols, mechanisms, and custom reports.

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Author’s Opinion: Most existing protocols focus on lists of agents rather than strategy. Without coordinated timing and synergy, their potential impact is greatly reduced. For tips on how to add real strategy to your protocol you can join our OncoForge Cancer Protocols Facebook group where tips are provided nearly daily. You can also request a custom protocol on this site. We do not provide medical advice, but we do provide valuable information.
Joe Tippens Protocol
Microtubules ↓NF-κB ↓STAT3 ↓COX-2 ↓TRPV1 / PPAR-γ ↑Anti-angiogenesis

Core Components & Dosing

  • Fenbendazole 222 mg (Panacur C) — 3 days ON / 4 days OFF
  • Curcumin 600 mg/day (high-bioavailability)
  • Vitamin E (γ-tocopherol) 400–800 IU/day
  • CBD Oil 25 mg/day
  • Add-ons: Quercetin | Berberine | Milk Thistle

Mechanistic Rationale

  • Fenbendazole → microtubule destabilisation → mitotic arrest
  • Curcumin / γ-tocopherol → NF-κB, STAT3, COX-2 inhibition
  • CBD → TRPV1 & PPAR-γ activation, anti-angiogenesis

Evidence Snapshot

  • Case reports & in-vitro / animal data; no RCTs
  • Protocol publicised after Joe Tippens’ SCLC remission (2017)

Cycle / Monitoring

  • Continuous; imaging q8–12 weeks
  • Liver panel & CBC q4–6 weeks

Key Cautions

  • Mild hepatotoxicity possible; rare neutropenia
  • High-dose γ-tocopherol may thin blood — monitor with anticoagulants
Dr. William Makis Protocol
WNT/β-catenin ↓Microtubules ↓P-gp ↓GLUT-1 ↓Glutamine blockMitochondrial collapse

Ivermectin Tiers

  • Low-grade 0.5 mg/kg · 3× week
  • Intermediate 1 mg/kg · 3× week
  • High-grade 1–2 mg/kg daily
  • Very aggressive ≤ 2.5 mg/kg daily

Benzimidazoles & DON

  • Mebendazole 200→400→1500 mg/day (grade-based)
  • Fenbendazole 1000 mg, 3× week (high-grade)
  • DON 0.2–0.6 mg/kg IV/IM or ≤ 1.1 mg/kg oral daily

Supportive Stack

  • IV Vitamin C 1.5 g/kg · 2–3× week
  • Vitamin D3 25–50 k IU/day (load) → 2 k IU/day (maint)
  • Zinc 1 mg/kg/day → 5 mg/day maintenance
  • Strict keto (< 20 g carbs) + 3–7-day water fasts q3–4 weeks
  • HBOT 1.5–2.5 ATA · 90 min · 2–3× week

Mechanistic Highlights

  • Ivermectin → WNT/TCF inhibition, mitochondrial collapse, P-gp block
  • Mebendazole/Fenbendazole → microtubule disruption; GLUT-1 down-reg
  • DON → glutamine antagonist, starves TCA cycle

Cycle / Monitoring

  • Typical length ≈ 12 weeks, then imaging & labs
  • Labs: CBC, CMP, vitamin D, ferritin, insulin, ketones, uric acid

Key Cautions

  • High-dose IVM → CNS effects if BBB compromised
  • LFTs with benzimidazoles; electrolyte shifts during fasting
Jane McLelland “Metro Map” Protocol
Glycolysis ↓Glutamine ↓FAO ↓Mitochondria ↓mTOR ↓NF-κB ↓

Fuel-Blocking Drug Blocks

  • Glucose block – Berberine 500 mg TID, Metformin 500 mg BID
  • Glutamine block – Dipyridamole 75–100 mg, Aspirin 75–150 mg
  • Fatty-acid block – Hydroxycitrate 500 mg TID, Statin 40 mg
  • Mito-block – Doxycycline 100 mg BID + Artemisinin/Niclosamide pulse

Rationale

  • Starves multiple metabolic routes simultaneously
  • Rotating / layering mimics multi-agent chemo with lower toxicity

Evidence & Monitoring

  • Case-series show durable responses in late-stage patients
  • Labs monthly; imaging q12 weeks

Key Cautions

  • Poly-pharmacy interaction risk (e.g., statin + azoles → rhabdo)
  • Aspirin/Dipyridamole ↑ bleeding — avoid peri-surgery
Care Oncology Clinic Quad
AMPK ↑mTOR ↓Mevalonate ↓Mito-biogenesis ↓Microtubules ↓

Standard Drug Quad

  • Metformin XR 500–1000 mg BID – AMPK ↑ / mTOR ↓
  • Atorvastatin 40 mg qHS – Mevalonate pathway ↓
  • Doxycycline 100 mg QD–BID – Mitochondrial biogenesis ↓
  • Mebendazole 100 mg QD (or 500 mg 3×/wk) – Microtubule disruptor

Clinical Evidence

  • UK registry (> 2000 pts) shows OS signal in GBM, TNBC, prostate
  • Prospective RCT underway for NSCLC + chemo-IO

Monitoring & Cautions

  • Liver panel & CK baseline + q12 weeks
  • Statin myalgias & Metformin GI upset common
Dr. Valter Longo – Fasting-Mimicking Diet
IGF-1 ↓mTOR ↓Autophagy ↑Ketogenesis ↑Stem-cell reset

Protocol Summary

  • 5-day plant-based kit: Day 1 ≈ 1100 kcal; Days 2–5 ≈ 750 kcal
  • Macros: 10% protein | 45% fat | 45% complex carbs
  • Cycle monthly or before chemo cycles

Mechanism

  • Reduces IGF-1, mTOR, glucose → stresses tumour cells
  • Re-feeding triggers hematopoietic regeneration

Data

  • Mouse: FMD + chemo doubles survival vs chemo alone
  • Phase II trials (breast, prostate) show ↑ QoL & ↓ toxicity

Cautions

  • Not for cachectic or BMI < 19 without supervision
Dr. Thomas Seyfried – Press-Pulse Metabolic Therapy
Ketosis ↑Glycolysis ↓mTOR ↓Mito-stressROS modulation

Core Elements

  • Ketogenic 4:1 diet, calories –20–30% below BMR
  • Pulse: 2-DG, HBOT, or exogenous ketones 2–3× week
  • Target GKI ≤ 2.0 via daily finger-stick

Supporting Evidence

  • Pre-clinical GBM: 80% tumour volume reduction
  • Case reports: multi-year NED in ND-GBM & Stage IV lung

Cautions

  • Ketoacidosis risk in uncontrolled diabetics; monitor electrolytes
Dr. Nicholas Gonzalez Enzyme Protocol
Proteolysis ↑Detox ↑Immune ↑

Daily Schedule

  • 130–175 pancreatic enzyme caps / day (6–8 doses)
  • 13 fresh vegetable juices, organic diet
  • 2–4 coffee enemas daily + liver flushes

Evidence

  • NIH pilot in pancreatic Ca: median OS 17.5 mo vs 4 mo historical
  • Randomised trial halted early; inconclusive

Cautions

  • High pill burden; risk of steatorrhea & electrolyte imbalance
Dr. Raymond Chang Integrative (AMRF) Protocol
COX-2 ↓Angiogenesis ↓NF-κB ↓Mito-blockImmune ↑

Typical Cocktail

  • Repurposed Rx: Metformin, Celecoxib, Cimetidine, Doxycycline
  • Botanicals: Artemisinin 600 mg pulse, Scutellaria 1 g, Curcumin 3 g
  • Immune mod: Low-dose IL-2, Mistletoe, β-glucans

Rationale & Data

  • Multi-target inhibition of angiogenesis, inflammation, stem-cell renewal
  • NYC clinic cohort shows OS extension in metastatic sarcoma & CRC

Cautions

  • Cimetidine inhibits CYP450 → ↑ many drug levels
Rick Simpson Oil (RSO)
CB1/CB2 ↑Apoptosis ↑Autophagy ↑Anti-angiogenesis

Dosing Ramp

  • Start 0.1 g/day, doubling every 4 days → 1 g/day
  • Maintain 1 g/day for 60–90 days (~ 60 g course)

Mechanism

  • High THC binds CB1/CB2 → apoptosis, autophagy, anti-angiogenesis

Cautions

  • Psychoactive; do not drive
  • Legal status varies; ensure solvent-free product
Budwig Protocol
Omega-3 ↑Mito function ↑Anti-inflammation

Daily Steps

  • Blend 2 tbsp flaxseed oil + ½ cup cottage cheese + berries
  • Pescatarian whole-food diet, no refined oils/sugar
  • 15 min sun exposure for vitamin D

Rationale

  • Linolenic acid + sulfur proteins improve electron transport

Cautions

  • PUFA oxidation if oil not fresh; monitor triglycerides
Gerson Therapy
Detox ↑Antioxidants ↑Immune ↑

Core Elements

  • 13 × 8 oz organic juices daily (hourly)
  • Up to 5 coffee enemas to boost glutathione-S-transferase
  • Supplements: potassium, Lugol’s iodine, pancreatin, B12

Evidence

  • Historical case series; controlled data lacking

Cautions

  • Risk of hyponatremia & hypocalcemia; needs medical oversight
Insulin-Potentiation Therapy (IPT)
Chemo sensitiserInsulin receptor ↑Toxicity ↓

Procedure

  • IV insulin → blood glucose ≈ 40 mg/dL
  • Low-dose chemo (10–15% standard) at nadir
  • Dextrose rescue + nutrients

Rationale

  • Cancer cells overexpress insulin receptors → absorb more chemo
  • Aims to keep efficacy while reducing systemic toxicity

Cautions

  • Severe hypoglycaemia risk; must be done by experienced team
  • Lack of large-scale trials; regulatory acceptance limited
Final Reminder: None of these protocols replace evidence-based oncology care. Always share alternative plans with your oncologist to manage interactions, imaging, and lab monitoring.