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⏰ Last updated December 3, 2025

12 Most Popular Alternative Cancer Protocols 2025: Fenbendazole, Ivermectin, Joe Tippens, Makis, Jane McLelland & More

In 2025 the alternative cancer landscape has never been more active. Reports of aggressive “turbo cancers,” long conventional-treatment wait times, and thousands of new anecdotal successes have driven explosive interest in drug repurposing (fenbendazole, ivermectin, mebendazole), metabolic approaches, and multi-pathway blocking strategies.

This page is the most detailed, continually updated comparison of the 12 most discussed protocols available anywhere – completely free. Every protocol below includes 2025 dosing updates, mechanistic rationale, latest evidence snapshot, monitoring tips, and key cautions.

Not medical advice—educational only. These protocols show preliminary preclinical/anecdotal promise but have failed many. Consult your oncologist; monitor labs/imaging closely. Outcomes vary wildly.

2025 Alternative Cancer Protocols – Quick Comparison Table

ProtocolCore Agents (2025)Key Pathways TargetedEvidence Level 2025Risk Profile
Joe TippensFenbendazole 444 mg daily + Curcumin + Vit E + CBDMicrotubules ↓ NF-κB ↓ STAT3 ↓ Anti-angiogenesisThousands of case reports + preclinicalBeginners, broad-spectrumLow
Dr William MakisIvermectin up to 2+ mg/kg + benzimidazoles + DON (aggressive)WNT ↓ Mitochondria collapse P-gp block GLUT-1 ↓Rapidly growing case series + preclinicalAggressive / turbo cancersMedium–High
Jane McLelland “Metro Map”Metformin + Berberine + Statin + Doxycycline + off-label blocksGlycolysis ↓ Glutamine ↓ FAO ↓ Mitochondria ↓ mTOR ↓Case series + mechanistic studiesLate-stage, multi-pathwayMedium
Care Oncology QuadMetformin + Atorvastatin + Doxycycline + MebendazoleAMPK ↑ mTOR ↓ Mevalonate ↓ Microtubules ↓Registry data (>2000 pts) + ongoing RCTsAdjunct to standard careLow–Medium
Valter Longo Fasting-Mimicking Diet5-day low-calorie plant-based cyclesIGF-1 ↓ mTOR ↓ Autophagy ↑ Ketogenesis ↑Phase II trials + preclinicalAll types, chemo sensitizerLow (supervised)
Thomas Seyfried Press-PulseStrict 4:1 keto + calorie restriction + pulses (HBOT, 2-DG, ketones)Ketosis ↑ Glycolysis ↓ mTOR ↓ ROS modulationPreclinical + case reports (multi-year NED)Brain cancers, metabolic-drivenMedium
Gonzalez Enzyme130–175 pancreatic enzymes/day + juices + enemasProteolysis ↑ Detox ↑ Immune ↑Historical case series + pilot dataPancreatic, digestive cancersHigh (pill burden)
Raymond Chang Integrative (AMRF)Metformin + Celecoxib + Artemisinin + MistletoeCOX-2 ↓ Angiogenesis ↓ NF-κB ↓ Immune ↑Clinic cohort dataMetastatic sarcoma/CRCMedium
Rick Simpson Oil (RSO)High-THC cannabis oil 1 g/dayCB1/CB2 ↑ Apoptosis ↑ Autophagy ↑Anecdotal + preclinicalPain, appetite, direct antitumorHigh (psychoactive)
Budwig ProtocolFlax oil + cottage cheese + sun exposureOmega-3 ↑ Mito function ↑ Anti-inflammationHistorical case seriesSupportive, foundationalLow
Gerson Therapy13 juices/day + coffee enemas + supplementsDetox ↑ Antioxidants ↑ Immune ↑Historical case seriesDetox-focusedHigh (electrolytes)
Insulin-Potentiated Therapy (IPT)Low-dose chemo with insulinChemo sensitizer Toxicity ↓Clinic data + limited trialsReduced side effectsHigh (hypoglycemia risk)

Joe Tippens Fenbendazole Protocol 2025 Update – Latest Dosage, Evidence & Synergies

Microtubules ↓NF-κB ↓STAT3 ↓COX-2 ↓TRPV1 / PPAR-γ ↑Anti-angiogenesis

2025 Core Components & Current Recommended Dosing

  • Fenbendazole 444 mg daily (two 1-g packets Panacur C or one 444 mg capsule) – most users now take 7 days/week
  • Curcumin 600 mg/day (high-bioavailability, e.g., Theracurmin or with piperine)
  • Vitamin E (succinate or γ-tocopherol preferred) 400–800 IU/day
  • CBD Oil (full-spectrum) 25 mg/day ( sublingual)
  • Common add-ons: Berberine, quercetin, milk thistle (liver support)

Note on original vs updated dosing: Joe originally used 222 mg for 3 days ON / 4 days OFF. He later increased to 444 mg daily and has publicly stated the higher dose is safe and preferred for most adults.

Mechanistic Rationale

  • Fenbendazole → microtubule destabilisation → mitotic arrest & p53 activation
  • Curcumin / Vitamin E → NF-κB, STAT3, COX-2 inhibition
  • CBD → TRPV1 & PPAR-γ activation, anti-angiogenesis, apoptosis

Evidence Snapshot 2025

  • Case reports & in-vitro / animal data; no RCTs
  • Protocol publicised after Joe Tippens’ SCLC remission (2017)
  • Thousands of new 2025 testimonials across private groups

Cycle / Monitoring

  • Continuous; imaging q8–12 weeks
  • Liver panel & CBC q4–6 weeks

Key Cautions

  • Mild hepatotoxicity possible; rare neutropenia
  • High-dose γ-tocopherol may thin blood — monitor with anticoagulants

Dr William Makis Ivermectin Cancer Protocol 2025 – Full Tiers, Safety Data & Latest Updates

WNT/β-catenin ↓Microtubules ↓P-gp ↓GLUT-1 ↓Glutamine blockMitochondrial collapse

Ivermectin Tiers (2025)

  • Low-grade 0.5 mg/kg · 3× week
  • Intermediate 1 mg/kg · 3× week
  • High-grade 1–2 mg/kg daily
  • Very aggressive ≤ 2.5 mg/kg daily

Benzimidazoles & DON

  • Mebendazole 200→400→1500 mg/day (grade-based)
  • Fenbendazole 1000 mg, 3× week (high-grade)
  • DON 0.2–0.6 mg/kg IV/IM or ≤ 1.1 mg/kg oral daily

Supportive Stack

  • IV Vitamin C 1.5 g/kg · 2–3× week
  • Vitamin D3 25–50 k IU/day (load) → 2 k IU/day (maint)
  • Zinc 1 mg/kg/day → 5 mg/day maintenance
  • Strict keto (< 20 g carbs) + 3–7-day water fasts q3–4 weeks
  • HBOT 1.5–2.5 ATA · 90 min · 2–3× week

Mechanistic Highlights

  • Ivermectin → WNT/TCF inhibition, mitochondrial collapse, P-gp block
  • Mebendazole/Fenbendazole → microtubule disruption; GLUT-1 down-reg
  • DON → glutamine antagonist, starves TCA cycle

Cycle / Monitoring

  • Typical length ≈ 12 weeks, then imaging & labs
  • Labs: CBC, CMP, vitamin D, ferritin, insulin, ketones, uric acid

Key Cautions

  • High-dose IVM → CNS effects if BBB compromised
  • LFTs with benzimidazoles; electrolyte shifts during fasting

Jane McLelland Metro Map Protocol 2025 – Off-Label Drugs, Fuel Blocking & Latest Updates

Glycolysis ↓Glutamine ↓FAO ↓Mitochondria ↓mTOR ↓NF-κB ↓

Fuel-Blocking Drug Blocks

  • Glucose block – Berberine 500 mg TID, Metformin 500 mg BID
  • Glutamine block – Dipyridamole 75–100 mg, Aspirin 75–150 mg
  • Fatty-acid block – Hydroxycitrate 500 mg TID, Statin 40 mg
  • Mito-block – Doxycycline 100 mg BID + Artemisinin/Niclosamide pulse

Rationale

  • Starves multiple metabolic routes simultaneously
  • Rotating / layering mimics multi-agent chemo with lower toxicity

Evidence & Monitoring 2025

  • Case-series show durable responses in late-stage patients
  • Labs monthly; imaging q12 weeks

Key Cautions

  • Poly-pharmacy interaction risk (e.g., statin + azoles → rhabdo)
  • Aspirin/Dipyridamole ↑ bleeding — avoid peri-surgery

Care Oncology Clinic Quad Protocol 2025 – Metformin, Statin, Doxycycline, Mebendazole Updates

AMPK ↑mTOR ↓Mevalonate ↓Mito-biogenesis ↓Microtubules ↓

Standard Drug Quad (2025)

  • Metformin XR 500–1000 mg BID – AMPK ↑ / mTOR ↓
  • Atorvastatin 40 mg qHS – Mevalonate pathway ↓
  • Doxycycline 100 mg QD–BID – Mitochondrial biogenesis ↓
  • Mebendazole 100 mg QD (or 500 mg 3×/wk) – Microtubule disruptor

Clinical Evidence 2025

  • UK registry (> 2000 pts) shows OS signal in GBM, TNBC, prostate
  • Prospective RCT underway for NSCLC + chemo-IO

Monitoring & Cautions

  • Liver panel & CK baseline + q12 weeks
  • Statin myalgias & Metformin GI upset common

Valter Longo Fasting-Mimicking Diet (FMD) 2025 – Protocol, Cycles & Latest Trial Data

IGF-1 ↓mTOR ↓Autophagy ↑Ketogenesis ↑Stem-cell reset

Protocol Summary

  • 5-day plant-based kit: Day 1 ≈ 1100 kcal; Days 2–5 ≈ 750 kcal
  • Macros: 10% protein | 45% fat | 45% complex carbs
  • Cycle monthly or before chemo cycles

Mechanism

  • Reduces IGF-1, mTOR, glucose → stresses tumour cells
  • Re-feeding triggers hematopoietic regeneration

Data 2025

  • Mouse: FMD + chemo doubles survival vs chemo alone
  • Phase II trials (breast, prostate) show ↑ QoL & ↓ toxicity

Cautions

  • Not for cachectic or BMI < 19 without supervision

Dr Thomas Seyfried Press-Pulse Metabolic Therapy 2025 – Keto, GKI Targets & Updates

Ketosis ↑Glycolysis ↓mTOR ↓Mito-stressROS modulation

Core Elements

  • Ketogenic 4:1 diet, calories –20–30% below BMR
  • Pulse: 2-DG, HBOT, or exogenous ketones 2–3× week
  • Target GKI ≤ 2.0 via daily finger-stick

Supporting Evidence 2025

  • Pre-clinical GBM: 80% tumour volume reduction
  • Case reports: multi-year NED in ND-GBM & Stage IV lung

Cautions

  • Ketoacidosis risk in uncontrolled diabetics; monitor electrolytes

Dr Nicholas Gonzalez Enzyme Protocol 2025 – Pancreatic Enzymes & Detox Updates

Proteolysis ↑Detox ↑Immune ↑

Daily Schedule

  • 130–175 pancreatic enzyme caps / day (6–8 doses)
  • 13 fresh vegetable juices, organic diet
  • 2–4 coffee enemas daily + liver flushes

Evidence

  • NIH pilot in pancreatic Ca: median OS 17.5 mo vs 4 mo historical
  • Randomised trial halted early; inconclusive

Cautions

  • High pill burden; risk of steatorrhea & electrolyte imbalance

Dr Raymond Chang Integrative AMRF Protocol 2025 – Repurposed Drugs & Immune Modulators

COX-2 ↓Angiogenesis ↓NF-κB ↓Mito-blockImmune ↑

Typical Cocktail

  • Repurposed Rx: Metformin, Celecoxib, Cimetidine, Doxycycline
  • Botanicals: Artemisinin 600 mg pulse, Scutellaria 1 g, Curcumin 3 g
  • Immune mod: Low-dose IL-2, Mistletoe, β-glucans

Rationale & Data

  • Multi-target inhibition of angiogenesis, inflammation, stem-cell renewal
  • NYC clinic cohort shows OS extension in metastatic sarcoma & CRC

Cautions

  • Cimetidine inhibits CYP450 → ↑ many drug levels

Rick Simpson Oil (RSO) Protocol 2025 – High-THC Cannabis Oil Dosing & Evidence

CB1/CB2 ↑Apoptosis ↑Autophagy ↑Anti-angiogenesis

Dosing Ramp

  • Start 0.1 g/day, doubling every 4 days → 1 g/day
  • Maintain 1 g/day for 60–90 days (~ 60 g course)

Mechanism

  • High THC binds CB1/CB2 → apoptosis, autophagy, anti-angiogenesis

Cautions

  • Psychoactive; do not drive
  • Legal status varies; ensure solvent-free product

Budwig Protocol 2025 – Flax Oil + Cottage Cheese Core & Modern Updates

Omega-3 ↑Mito function ↑Anti-inflammation

Daily Steps

  • Blend 2 tbsp flaxseed oil + ½ cup cottage cheese + berries
  • Pescatarian whole-food diet, no refined oils/sugar
  • 15 min sun exposure for vitamin D

Rationale

  • Linolenic acid + sulfur proteins improve electron transport

Cautions

  • PUFA oxidation if oil not fresh; monitor triglycerides

Gerson Therapy 2025 – Juices, Enemas & Detox Protocol Updates

Detox ↑Antioxidants ↑Immune ↑

Core Elements

  • 13 × 8 oz organic juices daily (hourly)
  • Up to 5 coffee enemas to boost glutathione-S-transferase
  • Supplements: potassium, Lugol’s iodine, pancreatin, B12

Evidence

  • Historical case series; controlled data lacking

Cautions

  • Risk of hyponatremia & hypocalcemia; needs medical oversight

Insulin-Potentiated Therapy (IPT) 2025 – Low-Dose Chemo Protocol & Clinic Data

Chemo sensitiserInsulin receptor ↑Toxicity ↓

Procedure

  • IV insulin → blood glucose ≈ 40 mg/dL
  • Low-dose chemo (10–15% standard) at nadir
  • Dextrose rescue + nutrients

Rationale

  • Cancer cells overexpress insulin receptors → absorb more chemo
  • Aims to keep efficacy while reducing systemic toxicity

Cautions

  • Severe hypoglycaemia risk; must be done by experienced team
  • Lack of large-scale trials; regulatory acceptance limited

Alternative Cancer Protocols – Frequently Asked Questions

What is the best alternative cancer protocol right now?

There is no universal “best”, it depends on cancer type, stage, and genetics. Joe Tippens (fenbendazole-based) is still the most popular and accessible for beginners. For aggressive or “turbo” cancers, Dr. William Makis’ high-dose ivermectin tiers are currently the fastest-growing approach in patient communities. Most advanced users now combine both with metabolic support.

Fenbendazole cancer dosage for humans – current recommendation?

444 mg daily (continuous, 7 days/week) is the current community standard. Many experienced users go to 888–1000 mg/day or pulse higher and take with fat to boost absorption.

Is the Joe Tippens protocol still working?

Yes – new case reports and testimonials continue to appear daily in private groups and peer-reviewed literature. Multiple 2024–2025 publications document complete remissions across different cancer types.

Can you combine ivermectin and fenbendazole?

Yes, and it’s one of the most common stacks right now. Fenbendazole hits microtubules and GLUT-1; ivermectin blocks WNT, P-gp, and causes mitochondrial collapse. Typical combo: fenbendazole 444 mg daily + ivermectin 1–2 mg/kg (daily or 3× week).

What is Dr. William Makis ivermectin cancer protocol?

Four aggression-based tiers from 0.5 mg/kg 3× week (low-grade) up to 2–2.5 mg/kg daily (very aggressive cancers), usually paired with mebendazole/fenbendazole, strict keto, high-dose vitamin D/zinc, and optional DON pulses.

Fenbendazole vs ivermectin – which is better for cancer?

No direct comparison trials exist. Fenbendazole is cheaper, better tolerated long-term, and easier to source. Ivermectin appears stronger against highly aggressive cancers. Most advanced protocols use both.

Has anyone been cured by fenbendazole?

Very few peer-reviewed case reports (lung, colon, breast, prostate, melanoma) document complete remission. However, there are A LOT of anecdotal successes shared in closed patient communities.

Jane McLelland protocol – still relevant?

Very much so. The “metro map” strategy of blocking glucose, glutamine, and fatty acids simultaneously remains one of the most sophisticated off-label approaches. Many users now add ivermectin or fenbendazole pulses.

Care Oncology protocol – worth doing?

Registry data on >2,000 patients continues to show survival benefit in GBM, prostate, and breast cancers. Easy, low-toxicity quad (metformin + atorvastatin + doxycycline + mebendazole). Many upgrade the mebendazole dose and add ivermectin.

Should I stop chemo to do alternative protocols?

Never without oncologist approval. The majority of reported successes use repurposed drugs alongside conventional treatment to increase efficacy and reduce side effects.

Best protocol for stage 4 cancer?

There's no one best protocol, but many people end up going with aggressive hybrids: Makis high-dose ivermectin + fenbendazole/mebendazole + strict metabolic therapy (keto <20 g carbs + intermittent fasting) + supportive stack report the highest response rates in patient communities, though this is based on anecdotal evidence.

Is mebendazole or fenbendazole better?

Mebendazole has slightly better brain penetration; fenbendazole is cheaper and has many anecdotal claims of efficacy.

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Final Reminder: None of these protocols replace evidence-based oncology care. Always share alternative plans with your oncologist to manage interactions, imaging, and lab monitoring.