Breast Invasive Ductal Carcinoma (IDC): Luminal A–like

Last reviewed: 9/15/2025

Applies to: ER+, PR high, HER2– with low Ki-67.

Summary

Endocrine-sensitive, lower-risk biology. Many node-negative cases avoid chemotherapy based on genomic assay support.

Pathology & Markers

  • ER+, PR high
  • HER2–
  • Low Ki-67

Biology & Pathways

  • ER signaling
  • CDK4/6 dependence

Clinical Challenges

  • Late recurrences; adherence to long endocrine therapy.

Imaging Notes

  • Standard breast imaging surveillance; no routine body scans when asymptomatic.

Management Modifiers

Related

Educational use only; not medical advice.