Appointment dossier — Glioblastoma
Bring this to your appointment. It summarizes what published studies report — it is not medical advice and does not say anything works. Decisions are yours and your care team’s.
Compounds studied in Glioblastoma
No studies or cited compounds on file for this cancer yet.
Open recruiting trials (18)
- NCT05039281 · Phase 1 / Phase 2 — Atezolizumab and Cabozantinib for the Treatment of Recurrent Glioblastoma (United States)
- NCT06016452 · Phase 2 — A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma (India)
- NCT06558214 · Phase 2 — OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial (United States)
- NCT07326566 · Phase 2 — Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII (United States)
- NCT06835803 · Phase 2 — Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial (United States)
- NCT07476794 · Phase 2 — Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma (Canada)
- NCT02977780 · Phase 2 — INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT) (United States)
- NCT04523688 · Phase 2 — Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumour Homogenate in Glioblastoma (Italy)
- NCT05768919 · Phase 1 / Phase 2 — Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas (United States)
- NCT04732065 · Phase 1 — ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (United States)
- NCT04573140 · Phase 1 — A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) (United States)
- NCT03383978 · Phase 1 — Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma (Germany)
- NCT06097975 · Phase 1 — A Clinical Trial on Combined (Neo-)Adjuvant Intravenous Plus Intracranial Administration of Ipilimumab and Nivolumab in Recurrent Glioblastoma (Belgium)
- NCT07464925 · Phase 1 — A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma (United States)
- NCT05283330 · Phase 1 — Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors (United States)
- NCT05879367 · Phase 1 — Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma (United States)
- NCT07426848 — OT SMILE: Occupational Therapy Group Intervention for Primary Brain Tumour Patients (Ireland)
- NCT07274397 — Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma (France)
Most-relevant first: trials that name Glioblastoma, then broader trials you may still qualify for. 321 recruiting trials name this cancer on ClinicalTrials.gov. Eligibility is decided by each trial's team — bring these NCT numbers to your appointment.
Questions to ask your oncologist
- Of the open trials I found (for example NCT05039281), am I eligible for any — here or at a larger cancer center?
- What is my exact diagnosis — the type, subtype, stage, and grade?
- Has my tumor had molecular or genomic testing (e.g. next-generation sequencing), and what did it find?
- Should I have inherited (germline) genetic testing, and could it affect my treatment or my family?
- What is the goal of treatment for me — cure, long-term control, or comfort?
- What are all of my standard treatment options, and what does each one involve?
- What is the realistic benefit of each option, in actual numbers?
- What are the most common and the most serious side effects, and how are they managed?
- How will we know if treatment is working, and how often will I be scanned or tested?
- If the first treatment doesn't work, what are the next options?
- Are there gentler options if I want to prioritize quality of life?
- Am I eligible for any clinical trials — here or at a larger/academic cancer center?
- Is my case reviewed by a multidisciplinary tumor board?
- Would a second opinion at a center that treats my cancer often be worthwhile?
- Could any of my prescriptions, over-the-counter drugs, or supplements interfere with treatment?
- Which symptoms are emergencies, and who do I call after hours?
- Should I see palliative or supportive care alongside my treatment?
- How will treatment affect my daily life, work, and (if it matters to me) fertility?
- What can I safely do myself — diet and activity — and is anything I'm taking risky?
- What will treatment cost, and is financial assistance available?
- Should my tumor tissue be stored (biobanked) for future testing or trials?