Appointment dossier — Intracranial Sarcoma
Bring this to your appointment. It summarizes what published studies report — it is not medical advice and does not say anything works. Decisions are yours and your care team’s.
Compounds studied in Intracranial Sarcoma
- Carboplatin — Human evidence · 2 positive · PMID 37508972, 26588458
- Etoposide — Human evidence · 2 positive · PMID 37508972, 26588458
- Ifosfamide — Human evidence · 2 positive · PMID 37508972, 26588458
“Positive” means a study reported a positive result — most are early lab/animal work that may not translate to people.
Open recruiting trials (18)
- NCT03382158 — International PPB/DICER1 Registry (United States)
- NCT06943521 · Phase 1 / Phase 2 — A Study of MT-4561 in Patients With Various Advanced Solid Tumors (United States)
- NCT05333458 · Phase 2 — Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial (United States)
- NCT05894018 · Phase 2 — Brachytherapy (Iodine-125 Seeds) and Fluzoparib Combination Therapy for Advanced Unresectable Soft Tissue Sarcoma (China)
- NCT02508038 · Phase 1 — Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors (United States)
- NCT04999761 · Phase 1 — AB122 Platform Study (Japan)
- NCT06892678 · Phase 1 / Phase 2 — DFMO Maintenance for Patients With Relapsed/Refractory Ewing Sarcoma or Osteosarcoma (United States)
- NCT07193550 · Phase 2 — A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE) (United States)
- NCT06151080 · Phase 2 — Lenalidomide Combined With G-CHOP in the Treatment of Newly Diagnosed DLBCL With FL (China)
- NCT02275286 · Phase 1 / Phase 2 — Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients (France)
- NCT01659203 · Phase 1 / Phase 2 — Proton or Photon RT for Retroperitoneal Sarcomas (United States)
- NCT04719156 · Phase 2 — Fluorescent Intra-operative Tumor Margin Examination (United States)
- NCT07460986 · Phase 1 / Phase 2 — A Phase Ib/II Study to Evaluate Safety and Efficacy of Bexmarilimab in Combination With Doxorubicin in Metastatic Soft-tissue Sarcoma. (Spain)
- NCT01042379 · Phase 2 — I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (United States)
- NCT04273061 · Phase 2 — Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity (Canada)
- NCT05735184 · Phase 1 — A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML (United States)
- NCT05210374 · Phase 1 — Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas (United States)
- NCT06760221 — Safety and Efficacy of Preoperative SBRT and Radical Surgery for Soft Tissue Sarcoma of Extremities (China)
Most-relevant first: trials that name Intracranial Sarcoma, then broader trials you may still qualify for. Eligibility is decided by each trial's team — bring these NCT numbers to your appointment.
Financial help to look into
- PAN Foundation — Copay assistance funds by diagnosis (funds open and close as money allows). https://www.panfoundation.org/
- HealthWell Foundation — Copay and premium assistance funds by disease. https://www.healthwellfoundation.org/
- CancerCare — financial assistance — Limited grants plus free financial counseling. https://www.cancercare.org/financial
- Family Reach — Help with everyday living costs (rent, transport, food) during treatment. https://familyreach.org/
- NeedyMeds — Searchable directory of drug patient-assistance and discount programs. https://www.needymeds.org/
For each medicine above, search manufacturer and nonprofit programs at medicineassistancetool.org.
Questions to ask your oncologist
- I've read that Carboplatin has been studied in people for Intracranial Sarcoma — what's the evidence, and is it an option or available in a trial for me?
- I've read that Etoposide has been studied in people for Intracranial Sarcoma — what's the evidence, and is it an option or available in a trial for me?
- I've read that Ifosfamide has been studied in people for Intracranial Sarcoma — what's the evidence, and is it an option or available in a trial for me?
- Of the open trials I found (for example NCT03382158), am I eligible for any — here or at a larger cancer center?
- What is my exact diagnosis — the type, subtype, stage, and grade?
- Has my tumor had molecular or genomic testing (e.g. next-generation sequencing), and what did it find?
- Should I have inherited (germline) genetic testing, and could it affect my treatment or my family?
- What is the goal of treatment for me — cure, long-term control, or comfort?
- What are all of my standard treatment options, and what does each one involve?
- What is the realistic benefit of each option, in actual numbers?
- What are the most common and the most serious side effects, and how are they managed?
- How will we know if treatment is working, and how often will I be scanned or tested?
- If the first treatment doesn't work, what are the next options?
- Are there gentler options if I want to prioritize quality of life?
- Am I eligible for any clinical trials — here or at a larger/academic cancer center?
- Is my case reviewed by a multidisciplinary tumor board?
- Would a second opinion at a center that treats my cancer often be worthwhile?
- Could any of my prescriptions, over-the-counter drugs, or supplements interfere with treatment?
- Which symptoms are emergencies, and who do I call after hours?
- Should I see palliative or supportive care alongside my treatment?
- How will treatment affect my daily life, work, and (if it matters to me) fertility?
- What can I safely do myself — diet and activity — and is anything I'm taking risky?