Folate receptor alpha (FRα) expression in tubo-ovarian and endometrial tumors: a study of 923 cases
The journal of pathology. Clinical research · Mar 2026 · immunohistochemical study on tissue microarrays using the VENTANA FOLR1 CDx assay with standardized scoring criteria
The study examined folate receptor alpha (FRα) expression by immunohistochemistry on tissue microarrays of 923 tubo-ovarian and endometrial tumors using the VENTANA FOLR1 CDx assay and standardized scoring. They found FRα expression most commonly in serous carcinomas (45% of HGSC, 25% LGSC) and less commonly in some endometrial serous and serous borderline tumors, while many other ovarian and endometrial tumor types were negative or rarely positive. The work is descriptive and does not report clinical outcomes or functional testing.
Reported effects: HGSC positive cases 45% · Low-grade serous carcinoma positive cases 25% · +4 more
Key findings
- HGSC (high-grade serous carcinoma): 45% positive cases
- Low-grade serous carcinoma: 25% positive cases
- Endometrial serous carcinoma: 11% positive cases
- Serous borderline tumor: 10% positive cases
- Endometrioid ovarian carcinoma: 2% positive cases
- Clear cell ovarian carcinoma: 1% positive cases
- Mucinous ovarian tumors, sex cord-stromal tumors, endometrial endometrioid carcinomas, undifferentiated and dedifferentiated carcinomas, and endometrial clear cell carcinomas were reported as negative
AI summary of the abstract, human-reviewed · Sep 2026. Describes what this study reported, not medical advice. View on PubMed · Full text