Research Radartracking 72 published studies · 21 human · 14 clinical trials · 14 cancer pages · updated Jun 2026Open the Research Map →

Research Radar

New PubMed studies on repurposed drugs and natural compounds in cancer — summarized in plain language and reviewed by a person before posting.

How to read this page. These studies are automatically collected from PubMed and summarized by AI from the abstract, then reviewed by a human before publishing. Each summary describes only what that study reported — most are early lab, animal, or small human studies, and findings often conflict. This is educational information, not medical advice, and not a recommendation to take anything. Always talk with your oncologist.
Topic tags. Each study is filed under its main topic. Anticancer studies are the default; these tags flag the other dimensions:
Safety — Safety & interactionsAbsorption (PK) — How it's absorbed (PK)Formulation — Formulation & deliverySupportive care — Symptom & supportive careMetabolism — Metabolism & pathwaysTrial — Clinical trialMechanism — Biomarker & mechanism
Showing studies that mention “serous carcinomas”.
1 of 72 studies
Human · observationalMechanismReported positiveLimited evidenceTier 3 · early human

The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma

BMC cancer · Jun 2015 · cell line experiments plus human tissue expression and survival analysis

ovarian epithelial carcinomaovarian cancermucinous ovarian tumorsserous carcinomas

This study looked at REG4 in ovarian epithelial carcinoma using SKOV3 cells and ovarian tissue samples. In cells, adding REG4 or making cells overexpress REG4 reduced apoptosis and increased proliferation, migration, invasion, and G2/S cell-cycle progression. In patient tissues, REG4 was more highly expressed in tumor samples than in normal ovarian tissue, and higher REG4 expression was linked with worse survival outcomes.

Key findings
  • REG4 overexpression and recombinant REG4 inhibited apoptosis in SKOV3 cells.
  • REG4 increased proliferation, migration, invasion, and G2/S progression in SKOV3 cells.
  • Wnt5a, p70s6k, survivin, and VEGF increased, while Bax decreased with REG4 overexpression.
  • REG4 mRNA and protein were higher in ovarian tumor tissues than in normal ovarian tissue.
  • Higher REG4 expression was associated with poorer cumulative and relapse-free survival.
Limitations: Primarily cell-line and tissue-expression study; no therapeutic intervention in patients.; Observational survival association cannot establish causality.; Abstract does not report sample sizes, effect sizes, or detailed statistical estimates.; Findings are based on one ovarian cancer cell line (SKOV3) and may not generalize to all ovarian cancers..

REG4 was studied as a biomarker and functional regulator in ovarian cancer, not as a repurposed drug or natural compound.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed · Full text