Ovarian Rhabdomyosarcoma: Alveolar (PAX–FOXO1+ subset)

Fusion-driven subset with higher nodal propensity and worse outcomes; requires aggressive multimodality care.

• PAX3/7–FOXO1 fusion by FISH/NGS in many cases
• Strong myogenin/MyoD1 nuclear staining

• PAX–FOXO1 transcriptional program
• IGF/PI3K/AKT dependence

• Higher risk of nodal and hematogenous spread
• Potential chemoresistance; consider trials early

• Chest CT essential; consider PET/CT for staging

• Back to Ovarian Rhabdomyosarcoma overview
• Ovarian Rhabdomyosarcoma: Embryonal
• Ovarian Rhabdomyosarcoma: Spindle cell / sclerosing
• Ovarian Rhabdomyosarcoma: Pleomorphic (adult)