Ovarian Rhabdomyosarcoma: Embryonal

Most reported gynecologic RMS subtype; may present in AYA. Managed with surgical resection plus VAC-based chemotherapy; RT as indicated.

• Desmin+, myogenin+, MyoD1+
• Usually fusion-negative for PAX–FOXO1

• Myogenic program activation
• PI3K/AKT/mTOR signaling

• Mass effect symptoms and risk of torsion/rupture
• Need for fertility counseling in AYA

• CT CAP baseline; MRI pelvis for local mapping

• Back to Ovarian Rhabdomyosarcoma overview
• Ovarian Rhabdomyosarcoma: Alveolar (PAX–FOXO1+ subset)
• Ovarian Rhabdomyosarcoma: Spindle cell / sclerosing
• Ovarian Rhabdomyosarcoma: Pleomorphic (adult)