Appointment dossier — Squamous Cervical Carcinoma
Bring this to your appointment. It summarizes what published studies report — it is not medical advice and does not say anything works. Decisions are yours and your care team’s.
Compounds studied in Squamous Cervical Carcinoma
- Cisplatin — Human evidence · 1 positive · PMID 23151423
- Topotecan — Human evidence · 1 positive · PMID 23151423
- Trastuzumab Deruxtecan — Human evidence · 1 positive · PMID 39639215
- Trastuzumab-Deruxtecan (T-Dxd) — Human evidence · 1 positive · PMID 39639215
- Pembrolizumab — Animal evidence · 1 positive · PMID 37469254
“Positive” means a study reported a positive result — most are early lab/animal work that may not translate to people.
Open recruiting trials (18)
- NCT04415853 · Phase 3 — Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer (China)
- NCT07070518 · Phase 1 / Phase 2 — Study of GV20-0251 in Participants With Solid Tumor Malignancies (China)
- NCT04119024 · Phase 1 — Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors (United States)
- NCT06778863 · Phase 1 — A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation (United States)
- NCT05266898 · Phase 4 — Immunogenicity of Gardasil-9 HPV Vaccine in People Living With HIV (United States)
- NCT06492460 · Phase 3 — 2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma (China)
- NCT06079671 · Phase 3 — Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical) (United States)
- NCT06693323 · Phase 2 — Single-Center Eval of Clinical & Radiological Benefit AHCC in Combo W/ SOC Tx for HPV+ Pts W/ HNSCC (United States)
- NCT06648096 · Phase 1 / Phase 2 — Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) (Germany)
- NCT07392580 · Phase 2 — Intralesional Chemotherapy (IC): Cisplatin + Epinephrine (United States)
- NCT05069857 · Phase 2 — Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients (China)
- NCT06006650 · Phase 2 — Neoadjuvant Therapy for Stage II-IVA Resectable Esophageal Squamous Cell (China)
- NCT07492914 · Phase 2 — Neoadjuvant Sacituzumab Govitecan Plus Tagitanlimab for Resectable Head and Neck Squamous Cell Carcinoma (China)
- NCT06780111 · Phase 1 / Phase 2 — Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) (United States)
- NCT06199895 · Phase 2 — Clinical Efficacy and Safety of Paclitaxel Polymeric Micelles for Injection in the Treatment of Patients With Taxans-resistant Pancreatic Adenocarcinoma, Cholangiocarcinoma, Lung Cancer, Gastric Cancer, Esophageal Carcinoma, or Breast Cancer (China)
- NCT04151082 · Phase 1 / Phase 2 — High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors (United States)
- NCT06540443 · Phase 1 — Pilot Study of MPB-2043 Enhanced MRI for Nodal Staging in Head and Neck Squamous Cell Carcinomas (Taiwan)
- NCT06589609 · Phase 1 — Phase 1 Clinical Trial of FluBHPVE6E7 Immunotherapy for HPV16-Associated Oropharyngeal Cancer (Austria)
Most-relevant first: trials that name Squamous Cervical Carcinoma, then broader trials you may still qualify for. 648 recruiting trials name this cancer on ClinicalTrials.gov. Eligibility is decided by each trial's team — bring these NCT numbers to your appointment.
Financial help to look into
- PAN Foundation — Copay assistance funds by diagnosis (funds open and close as money allows). https://www.panfoundation.org/
- HealthWell Foundation — Copay and premium assistance funds by disease. https://www.healthwellfoundation.org/
- CancerCare — financial assistance — Limited grants plus free financial counseling. https://www.cancercare.org/financial
- Family Reach — Help with everyday living costs (rent, transport, food) during treatment. https://familyreach.org/
- NeedyMeds — Searchable directory of drug patient-assistance and discount programs. https://www.needymeds.org/
For each medicine above, search manufacturer and nonprofit programs at medicineassistancetool.org.
Questions to ask your oncologist
- I've read that Cisplatin has been studied in people for Squamous Cervical Carcinoma — what's the evidence, and is it an option or available in a trial for me?
- I've read that Topotecan has been studied in people for Squamous Cervical Carcinoma — what's the evidence, and is it an option or available in a trial for me?
- I've read that Trastuzumab Deruxtecan has been studied in people for Squamous Cervical Carcinoma — what's the evidence, and is it an option or available in a trial for me?
- Of the open trials I found (for example NCT04415853), am I eligible for any — here or at a larger cancer center?
- What is my exact diagnosis — the type, subtype, stage, and grade?
- Has my tumor had molecular or genomic testing (e.g. next-generation sequencing), and what did it find?
- Should I have inherited (germline) genetic testing, and could it affect my treatment or my family?
- What is the goal of treatment for me — cure, long-term control, or comfort?
- What are all of my standard treatment options, and what does each one involve?
- What is the realistic benefit of each option, in actual numbers?
- What are the most common and the most serious side effects, and how are they managed?
- How will we know if treatment is working, and how often will I be scanned or tested?
- If the first treatment doesn't work, what are the next options?
- Are there gentler options if I want to prioritize quality of life?
- Am I eligible for any clinical trials — here or at a larger/academic cancer center?
- Is my case reviewed by a multidisciplinary tumor board?
- Would a second opinion at a center that treats my cancer often be worthwhile?
- Could any of my prescriptions, over-the-counter drugs, or supplements interfere with treatment?
- Which symptoms are emergencies, and who do I call after hours?
- Should I see palliative or supportive care alongside my treatment?
- How will treatment affect my daily life, work, and (if it matters to me) fertility?
- What can I safely do myself — diet and activity — and is anything I'm taking risky?