Research Radartracking 4 published studies · 1 human · 2 clinical trials · 2 cancer pages · updated Jun 2026Open the Research Map →

Actinomycin D

← All agents

Human-reviewed · How we review →

AI extractedhuman reviewedsources checkedretractions suppressed

Evidence at a glanceInsufficient evidenceInconclusive
1 published studies tagged to this agent0 human studies (trial, observational, or meta-analysis)
Why this grade?

Insufficient evidenceNo primary experimental studies yet.

Computed deterministically from the studies’ types and reported outcomes — not written by AI, and not a claim that anything works.

Auto-discovered · not yet curatedactinomycin d
Educational only, not medical advice. OncoForge makes no claim that Actinomycin D treats, prevents, or cures any condition, beyond what the linked studies show. Evidence levels vary; effects may not translate to people, and some compounds can cause harm. Always coordinate with your oncology team.

Simple Summary

Auto-discovered from 1 recent study; not yet curated.

Research

What supports this page

The kinds of sources behind this page, strongest at the top. Faint rungs show what is not here yet.

Guideline
0
Meta-analysis
0
Systematic review
0
Randomized trial
0
Clinical trial
0
Observational
0
Case report
1
Review
0
Preclinical
0
Other
0
1 studies1 review/other

Tracking 1 published study of Actinomycin D: 1 reviews/other.

Reported direction across studies: 1 inconclusive.

No human studies yet — these are preclinical (lab/animal) findings that may not translate to people.

These counts summarize what the studies reported; they are not a measure of whether Actinomycin D works.

Cancers named in these studies

ovarian rhabdomyosarcoma (1)

All studies

Case reportInconclusiveLimited evidenceTier 3 · early humann = 1

Primary ovarian rhabdomyosarcoma: A diagnostic dilemma in an uncommon tumor

Journal of cancer research and therapeutics · Oct 2025 · case report

CyclophosphamideActinomycin-dVincristineovarian rhabdomyosarcoma

This case report describes a 17-year-old girl with a very rare ovarian rhabdomyosarcoma. The tumor was diagnosed by imaging, pathology, and immunohistochemistry, and it came back within 3 months after surgery. The authors report that she then received VAC chemotherapy (vincristine, actinomycin D, and cyclophosphamide), and they emphasize the need for earlier diagnosis and more standardized treatment approaches.

Studied with: vincristine, actinomycin D, cyclophosphamide.

Key findings
  • Imaging showed a large solid-cystic pelvic mass.
  • Histopathology and immunohistochemical markers (desmin, myogenin, WT1) confirmed ovarian rhabdomyosarcoma.
  • Recurrence occurred within 3 months after surgical resection.
  • VAC chemotherapy was given after early relapse.
Limitations: Single-patient case report.; No control group.; No quantitative treatment outcome data reported.; Cannot determine effectiveness of VAC from this report alone.; Focus is diagnostic and descriptive rather than evaluative..

Describes a rare ovarian cancer case and subsequent chemotherapy, but does not evaluate a compound's anticancer effect in a comparative way.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

What changed recently

The latest additions to Actinomycin D's evidence base, and anything that's been retracted.

Recently added

Evidence at a glance: Actinomycin D by cancer

A deterministic grade of what published studies report for each: strength of evidence, the reported direction, and the largest credible effect, strongest-evidence first. This summarizes findings; it is not a claim that anything works.

Ovarian rhabdomyosarcomaInsufficient evidenceInconclusive

No primary experimental studies yet.

Most authoritative study: Primary ovarian rhabdomyosarcoma: A diagnostic dilemma in an uncommon tumor

No human studies yet · No numeric effect sizes reported · Based on a single study.

Trials studying Actinomycin D

Loading current trials from ClinicalTrials.gov… Search ClinicalTrials.gov →

Inclusion here is not an endorsement. OncoForge makes no claim beyond what the linked studies show. Discuss anything on this page with your oncology team before acting on it.

← All agents · Research Radar