Research Radartracking 4 published studies · 1 human · 2 clinical trials · 2 cancer pages · updated Jun 2026Open the Research Map →

Vincristine

← All agents

Human-reviewed · How we review →

AI extractedhuman reviewedsources checkedretractions suppressed

Evidence at a glanceInsufficient evidenceReported positive
2 published studies tagged to this agent0 human studies (trial, observational, or meta-analysis)
Why this grade?

Insufficient evidenceNo primary experimental studies yet.

Computed deterministically from the studies’ types and reported outcomes — not written by AI, and not a claim that anything works.

Auto-discovered · not yet curatedvincristine
Educational only, not medical advice. OncoForge makes no claim that Vincristine treats, prevents, or cures any condition, beyond what the linked studies show. Evidence levels vary; effects may not translate to people, and some compounds can cause harm. Always coordinate with your oncology team.

Simple Summary

Auto-discovered from 2 recent studies; not yet curated.

Research

Where the evidence is

What has been studied, and how strong it is, by topic. A dashed cell means no studies were found for that combination — a gap, not evidence of no effect. Open a row to see its studies.

CancerHuman evidenceMechanismSafetyTrial
Ovarian Rhabdomyosarcoma11
Alveolar Rhabdomyosarcoma1
Embryonal Rhabdomyosarcoma1

What supports this page

The kinds of sources behind this page, strongest at the top. Faint rungs show what is not here yet.

Guideline
0
Meta-analysis
0
Systematic review
0
Randomized trial
0
Clinical trial
0
Observational
0
Case report
2
Review
0
Preclinical
0
Other
0
2 studies2 review/other

Tracking 2 published studies of Vincristine: 2 reviews/other.

Reported direction across studies: 1 positive, 1 inconclusive.

No human studies yet — these are preclinical (lab/animal) findings that may not translate to people.

These counts summarize what the studies reported; they are not a measure of whether Vincristine works.

Cancers named in these studies

ovarian rhabdomyosarcoma (2)alveolar rhabdomyosarcoma (1)embryonal rhabdomyosarcoma (1)

All studies

Case reportInconclusiveLimited evidenceTier 3 · early humann = 1

Primary ovarian rhabdomyosarcoma: A diagnostic dilemma in an uncommon tumor

Journal of cancer research and therapeutics · Oct 2025 · case report

CyclophosphamideActinomycin-dVincristineovarian rhabdomyosarcoma

This case report describes a 17-year-old girl with a very rare ovarian rhabdomyosarcoma. The tumor was diagnosed by imaging, pathology, and immunohistochemistry, and it came back within 3 months after surgery. The authors report that she then received VAC chemotherapy (vincristine, actinomycin D, and cyclophosphamide), and they emphasize the need for earlier diagnosis and more standardized treatment approaches.

Studied with: vincristine, actinomycin D, cyclophosphamide.

Key findings
  • Imaging showed a large solid-cystic pelvic mass.
  • Histopathology and immunohistochemical markers (desmin, myogenin, WT1) confirmed ovarian rhabdomyosarcoma.
  • Recurrence occurred within 3 months after surgical resection.
  • VAC chemotherapy was given after early relapse.
Limitations: Single-patient case report.; No control group.; No quantitative treatment outcome data reported.; Cannot determine effectiveness of VAC from this report alone.; Focus is diagnostic and descriptive rather than evaluative..

Describes a rare ovarian cancer case and subsequent chemotherapy, but does not evaluate a compound's anticancer effect in a comparative way.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

Case reportTrialReported positiveLimited evidenceTier 3 · early humann = 2

Primary ovarian rhabdomyosarcoma in children

Pediatric surgery international · May 2008 · case reports

CyclophosphamideVincristineDoxorubicinovarian rhabdomyosarcomaalveolar rhabdomyosarcomaembryonal rhabdomyosarcoma

This report describes two children with very rare primary ovarian rhabdomyosarcoma. After complete surgical removal, both received chemotherapy with vincristine, doxorubicin, and cyclophosphamide and had a good response. Both patients were alive 8 and 9 months after surgery.

Key findings
  • Two pediatric cases of primary ovarian rhabdomyosarcoma were described.
  • Both patients underwent complete resection of the primary tumor.
  • Both received vincristine, doxorubicin, and cyclophosphamide chemotherapy.
  • The abstract reports a good response to therapy and survival at 8 and 9 months post-operatively.
Limitations: Case report with only 2 patients.; No control group.; Short follow-up.; Cannot separate the effect of surgery from chemotherapy.; No dosing details reported..

Describes management of a rare ovarian cancer in children, including chemotherapy, but does not isolate the effect of any single compound.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

What changed recently

The latest additions to Vincristine's evidence base, and anything that's been retracted.

Recently added

Cancers where Vincristine reported positive results

Where at least one study reported a positive result, shown with the full picture, not just the wins. Positive results are more likely to be published, and most of these are early lab or animal studies that may not translate to people. This reports what studies found, not what works.

Preclinical only: lab / animal (3)
Limitations: Case report with only 2 patients.; No control group.; Short follow-up.; Cannot separate the effect of surgery from chemotherapy.; No dosing details reported..
Cited positive studies (1)
Alveolar rhabdomyosarcoma1 positive
Limitations: Case report with only 2 patients.; No control group.; Short follow-up.; Cannot separate the effect of surgery from chemotherapy.; No dosing details reported..
Cited positive studies (1)
Embryonal rhabdomyosarcoma1 positive
Limitations: Case report with only 2 patients.; No control group.; Short follow-up.; Cannot separate the effect of surgery from chemotherapy.; No dosing details reported..
Cited positive studies (1)

Evidence at a glance: Vincristine by cancer

A deterministic grade of what published studies report for each: strength of evidence, the reported direction, and the largest credible effect, strongest-evidence first. This summarizes findings; it is not a claim that anything works.

Ovarian rhabdomyosarcomaInsufficient evidenceReported positive

No primary experimental studies yet.

Most authoritative study: Primary ovarian rhabdomyosarcoma: A diagnostic dilemma in an uncommon tumor

No human studies yet · No numeric effect sizes reported · All studies are small (n < 30).
Alveolar rhabdomyosarcomaInsufficient evidenceReported positive

No primary experimental studies yet.

Most authoritative study: Primary ovarian rhabdomyosarcoma in children

No human studies yet · No numeric effect sizes reported · Based on a single study.
Embryonal rhabdomyosarcomaInsufficient evidenceReported positive

No primary experimental studies yet.

Most authoritative study: Primary ovarian rhabdomyosarcoma in children

No human studies yet · No numeric effect sizes reported · Based on a single study.

Trials studying Vincristine

Loading current trials from ClinicalTrials.gov… Search ClinicalTrials.gov →

Inclusion here is not an endorsement. OncoForge makes no claim beyond what the linked studies show. Discuss anything on this page with your oncology team before acting on it.

← All agents · Research Radar