Research Radartracking 1,138 published studies · 277 human · 6 safety signals · 42 clinical trials · 44 cancer pages · updated Jul 2026Open the Research Map →

Cisplatin

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Human-reviewed · How we review →

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Evidence at a glanceHuman trial / meta-analysisMixed results⚠ Studies disagree
12 published studies tagged to this agent6 human studies approved & graded (trial, observational, or meta-analysis)
Why this grade?

Human trial / meta-analysisIncludes human trial or meta-analysis evidence.

Computed deterministically from the studies’ types and reported outcomes — not written by AI, and not a claim that anything works.

Auto-discovered · not yet curatedcisplatin
Educational only, not medical advice. OncoForge makes no claim that Cisplatin treats, prevents, or cures any condition, beyond what the linked studies show. Evidence levels vary; effects may not translate to people, and some compounds can cause harm. Always coordinate with your oncology team.

Simple Summary

Auto-discovered from 1 recent study; not yet curated.

Research

Where the evidence is

What has been studied, and how strong it is, by topic. A dashed cell means no studies were found for that combination — a gap, not evidence of no effect. Open a row to see its studies.

CancerHuman evidenceMechanismSafetyTrial
Epithelial Ovarian Cancer111
Ovarian Carcinosarcoma211
Adenosquamous Cervical Carcinoma11
High Grade Endometrioid Ovarian Cancer11
High Grade Serous Ovarian Cancer11
Locally Advanced Cervical Cancer (Figo Ib2, Iia, Iib)11
Recurrent Ovarian Cancer11
Squamous Cervical Carcinoma11
Cervical Squamous Carcinoma11
Uterine Leiomyosarcoma11
Advanced Or Metastatic High Grade Epithelial Ovarian Cancer11
Clear Cell Adenocarcinoma (Ovarian)1
High Grade Epithelial Ovarian Cancer11
Lung Cancer1
Mixed Germ Cell Tumor Of Fallopian Tube
Non Small Cell Lung Cancer1

Reported figures

Study mix

12 published studies by what they were done in. Lab and animal findings often do not carry over to people.

6 Human1 Animal5 Review/other
Reported directionReported positive5Mixed results2Reported negative2Inconclusive3

What supports this page

The kinds of sources behind this page, strongest at the top. Faint rungs show what is not here yet.

Guideline
0
Meta-analysis
1
Systematic review
0
Randomized trial
0
Clinical trial
2
Observational
3
Case report
2
Review
3
Preclinical
1
Other
0
12 studies6 human1 animal5 review/other

Tracking 12 published studies of Cisplatin: 6 in humans, 1 in animals, 5 reviews/other.

Reported direction across studies: 5 positive, 2 mixed, 2 negative, 3 inconclusive.

Findings conflict — both supportive and negative/mixed results exist (see below). Human evidence is limited.

These counts summarize what the studies reported; they are not a measure of whether Cisplatin works.

Cancers named in these studies

epithelial ovarian cancer (2)ovarian carcinosarcoma (2)recurrent ovarian cancer (1)high-grade serous ovarian cancer (1)high-grade endometrioid ovarian cancer (1)advanced or metastatic high-grade epithelial ovarian cancer (1)high-grade epithelial ovarian cancer (1)ovarian epithelial carcinoma (1)non-small-cell lung cancer (1)lung cancer (1)

Conflicting evidence

Reported positive (5)

Negative or mixed (4)

All studies

Human trialTrialReported positiveStrong evidenceTier 4 · clinicaln = 415

Hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer (CHIPOR): a randomised, open-label, phase 3 trial

The Lancet. Oncology · Dec 2024 · randomised, open-label, phase 3, multicentre trial

Cisplatinepithelial ovarian cancerrecurrent ovarian cancerhigh-grade serous ovarian cancerhigh-grade endometrioid ovarian cancer

This multicentre, randomized phase 3 trial compared cytoreductive surgery with or without intraoperative hyperthermic intraperitoneal cisplatin (HIPEC) in 415 women with first relapse of epithelial ovarian cancer. At a median 6.2 years follow-up, HIPEC improved overall survival (stratified HR 0.73, p=0.024; median OS 54.3 vs 45.8 months) but was associated with higher rates of grade 3 or worse adverse events within 60 days (49% vs 27%).

Reported effects: stratified hazard ratio for overall survival 0.73 [0.56–0.96], p=0.024, n=415 · median overall survival 54.3 mo [41.9–61.7], n=415 · +7 more

Studied with: cytoreductive surgery, platinum-based chemotherapy, bevacizumab (optional), planned PARP inhibitor use (stratification).

Key findings
  • 415 patients randomised: 207 to HIPEC and 208 to no HIPEC.
  • Overall survival was significantly improved with HIPEC (stratified hazard ratio 0⋅73, 95% CI 0⋅56-0⋅96; p=0⋅024).
  • Median overall survival was 54⋅3 months (95% CI 41⋅9-61⋅7) with HIPEC versus 45⋅8 months (38⋅9-54⋅2) without.
  • At primary analysis 268 (65%) patients had died (126 [61%] of 207 in the HIPEC group; 142 [68%] of 208 in the no-HIPEC group).
  • Grade 3 or worse adverse events within 60 days occurred in 102 (49%) of 207 receiving HIPEC versus 56 (27%) of 208 receiving no HIPEC; common events included anaemia (47 [23%] vs 30 [14%]), hepatotoxicity (23 [11%] vs 18 [9%]), electrolyte disturbance (28 [14%] vs two [1%]), and renal failure (20 [10%] vs three [1%]).
  • There were three deaths within 60 days of surgery, all in the no-HIPEC group.
Limitations: Open-label design (no blinding).; Increased perioperative grade 3+ toxicity with HIPEC compared with no HIPEC.; Eligibility limited to patients with a first relapse ≥6 months after platinum-based chemotherapy who were amenable to complete cytoreduction; results may not generalise to other patient groups.; Optional use of bevacizumab and later planned PARP inhibitor use introduce heterogeneity in systemic therapy.; Conducted at specialist centres; generalisability to non-specialist settings is uncertain..

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

ReviewTrialInconclusiveLimited evidenceTier 4 · clinicaln = 11

Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer

Revista colombiana de obstetricia y ginecologia · Jun 2024 · expert consensus / practice guideline based on literature review

BevacizumabAnastrozoleCisplatinGemcitabineTopotecanOlaparibNiraparibCarboplatinLiposomal-doxorubicinPaclitaxelTamoxifenRucaparibadvanced or metastatic high-grade epithelial ovarian cancerhigh-grade epithelial ovarian cancerovarian epithelial carcinoma

This paper is an expert consensus, not a clinical study of a single drug. Eleven specialists reviewed the literature and issued recommendations for managing advanced or metastatic high-grade epithelial ovarian cancer, including surgery, chemotherapy, genetic testing, bevacizumab, and PARP inhibitors. It does not report new patient outcomes from a trial. The document mainly summarizes what the panel suggested based on existing guidelines and evidence.

Studied with: platinum-based chemotherapy, bevacizumab, paclitaxel, carboplatin.

Key findings
  • The panel suggested primary cytoreductive surgery as the initial approach when complete resection is feasible.
  • Neoadjuvant chemotherapy followed by interval surgery was suggested when complete cytoreduction is unlikely or the patient has poor functional status/comorbidities.
  • Bevacizumab was suggested with platinum-based chemotherapy for high-risk disease, with maintenance only if it was part of first-line therapy.
  • PARP inhibitors (olaparib, niraparib, rucaparib) were suggested as maintenance in selected BRCA/HRD-defined groups.
  • For platinum-resistant relapse, sequential non-platinum single-agent chemotherapy and best supportive care for poor performance status were suggested.
Limitations: This is a consensus statement/practice guideline, not an original comparative trial.; No new efficacy or safety data are reported in the abstract.; Recommendations are based on literature review and expert agreement, so they are subject to guideline-selection and expert-opinion bias.; The abstract does not provide patient-level outcomes, follow-up, or effect estimates.; Several recommendations are conditional/suggested rather than based on direct evidence from this paper..

Provides management recommendations for advanced/metastatic epithelial ovarian cancer, including several anticancer agents and maintenance strategies.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed · Full text

ReviewMechanismMixed resultsLimited evidenceTier 4 · clinical

Platinum-based targeted chemotherapies and reversal of cisplatin resistance in non-small cell lung cancer (NSCLC)

Mutation research · Jan 2024 · narrative review

Cisplatinnon-small-cell lung cancerlung cancerNSCLC

This narrative review summarizes platinum-based targeted chemotherapies in non-small-cell lung cancer (NSCLC), with a focus on cisplatin. It describes the NSCLC tumor microenvironment, cisplatin's mechanism of action, mechanisms of cisplatin resistance in NSCLC, and strategies proposed to reverse that resistance.

Key findings
  • Lung cancer is highly prevalent and has a poor prognosis; NSCLC recurrences are common after surgery.
  • Cisplatin is described as the more active platinum drug recommended for patients with advanced NSCLC and for early-stage patients needing adjuvant therapy.
  • The review covers the NSCLC microenvironment, treatment approaches, cisplatin mechanism of action, cisplatin resistance in NSCLC, and prevention strategies to revert drug resistance.
Limitations: Narrative review — no original experimental or clinical data are presented in the abstract.; Abstract does not describe review methods (e.g., search strategy, inclusion criteria) or any quantitative synthesis.; No numeric clinical outcomes or trial results are reported in the abstract..

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

Case reportReported positiveLimited evidenceTier 3 · early humann = 1

Malignant germ cell tumor of fallopian tube with rhabdomyosarcoma: a case report and literature review

Diagnostic pathology · Sep 2023 · case report and literature review

EtoposideCisplatinmixed germ cell tumor of fallopian tuberhabdomyosarcoma

This is a case report of a 34-year-old woman with a mixed germ cell tumor of the fallopian tube that included high-grade rhabdomyosarcoma components. She underwent extensive surgical resection followed by three cycles of BEP chemotherapy and one cycle of EP; at regular follow-up her tumor markers and imaging were normal and tumor-free survival reached 24 months.

Reported effect: tumor_free_survival 24 mo, n=1

Studied with: BEP (Bleomycin + Etoposide + Cisplatin), EP (Etoposide + Cisplatin).

Key findings
  • Patient: 34-year-old woman presented with abdominal pain.
  • Surgery performed: transabdominal resection of large left tubal masses, pelvic lymph node dissection, abdominal paraaortic lymph node dissection, right ovarian cyst excision, greater omentectomy, and multipoint peritoneal biopsy.
  • Pathology: hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining used to characterize the tumor (mixed germ cell tumor with high-grade rhabdomyosarcoma component).
  • Adjuvant chemotherapy: 3 cycles of BEP (Bleomycin + Etoposide + Cisplatin) and 1 cycle of EP (Etoposide + Cisplatin).
  • Outcome: regular follow-up showed normal tumor markers and imaging, with tumor-free survival reaching 24 months.
Limitations: Single-patient case report — no control group and limited generalizability.; No dosing amounts/administration details for chemotherapy provided in the abstract.; Follow-up limited to 24 months as reported; longer-term outcomes beyond that are not reported in the abstract.; Outcomes from a single case cannot establish efficacy or safety of the treatment..

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed · Full text

Human · observationalReported positiveLimited evidenceTier 3 · early humann = 58

Targeting homologous recombination deficiency in uterine leiomyosarcoma

Journal of experimental & clinical cancer research : CR · May 2023

OlaparibCisplatinuterine leiomyosarcoma

The authors screened 58 individuals with uterine leiomyosarcoma for homologous recombination deficiency (HRD) and identified 5 cases (9%). All five accessed PARP inhibitor therapy; in three patients with mature follow-up two achieved a complete response or durable partial response after platinum was added to PARPi. In patient-derived xenografts, the PARP1-specific inhibitor AZD5305 produced the most rapid, complete and sustained responses compared with olaparib or olaparib plus cisplatin, including in a BRCA2-deleted PDX that had developed PARPi-resistance mutations.

Reported effects: WGS samples with COSMIC signature 3 13, n=13 · WGS samples with high genome-wide LOH (> 0.2) 11, n=13 · +4 more

Studied with: cisplatin.

Key findings
  • All 13 uLMS samples analysed by WGS had a dominant COSMIC mutational signature 3.
  • 11 of the 13 WGS samples had high genome-wide loss of heterozygosity (> 0.2).
  • Only two WGS samples had a CHORD score > 50%; one of these had a homozygous pathogenic BRCA2 deletion.
  • A further three samples harboured homozygous HRD alterations (all deletions in BRCA2) detected by WES or panel sequencing, giving 5/58 (9%) individuals with HRD uLMS.
  • All five individuals with HRD gained access to PARPi therapy; two of three with mature clinical follow-up achieved a complete response or durable partial response after platinum was added to PARPi upon minor progression.
  • In corresponding PDX models, AZD5305 produced the most rapid, complete and sustained responses compared with olaparib alone or olaparib plus cisplatin, including in a BRCA2-deleted PDX that had developed PARPi-resistance mutations in PRKDC (DNA-PKcs).
Limitations: Small number of HRD cases (5 of 58), with only three patients having mature clinical follow-up.; Non-randomized, observational access to PARPi in patients (no control arm reported).; PDX (preclinical) findings may not fully predict clinical efficacy.; Sequencing methods varied across samples (WGS, WES, panel), and some genomic HRD metrics (CHORD) were discordant.; No dosing, schedule, or detailed treatment-response durations provided in the abstract..

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed · Full text

Human · observationalMechanismReported negativeLimited evidenceTier 3 · early humann = 35

Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT

BMC cancer · Aug 2019 · Analysis of protein expression by western blot and immunohistochemistry in paired tumor and adjacent tissues (13 pairs), and correlation of pre- and post-chemotherapy paired tumor samples (35 pairs) with clinical response to cisplatin-based neoadjuvant chemotherapy

Cisplatincervical squamous carcinoma

The authors measured thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 protein levels in cervical squamous carcinoma and adjacent tissues, and examined associations with response to cisplatin-based neoadjuvant chemotherapy in 35 patients. Expression of these proteins was higher in tumor than adjacent tissue, increased after chemotherapy, and higher expression levels were associated with a poorer chemotherapy response. Overall 48.6% (17/35) of patients had a clinical response (14.3% complete, 34.3% partial).

Reported effects: clinical response 48.6%, n=35 · complete response 14.3%, n=35 · +1 more

Studied with: cisplatin-based neoadjuvant chemotherapy.

Key findings
  • In an initial analysis of 13 paired samples, thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 expression was higher in cervical squamous cancer tissues than in adjacent non-cancerous tissues by western blotting and immunohistochemistry.
  • In 35 paired tumor samples (pre- and post-chemotherapy), expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 was significantly up-regulated in post-chemotherapy tissues compared to pre-chemotherapy tissues.
  • High levels of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 were associated with a poor response to cisplatin-based neoadjuvant chemotherapy.
  • A clinical response occurred in 48.6% (17/35) of patients, including 14.3% (5/35) complete responses and 34.3% (12/35) partial responses.
Limitations: Relatively small sample size (main correlation cohort n=35; initial western blot n=13).; Observational, correlative study design; association does not prove causation or mechanism.; No independent validation cohort reported in the abstract.; Abstract provides no details on chemotherapy dosing, schedule, or potential clinical covariates.; No functional experiments reported in the abstract to demonstrate that these proteins cause chemoresistance..

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed · Full text

Human trialTrialReported positiveLimited evidenceTier 4 · clinicaln = 92

Weekly topotecan and cisplatin (TOPOCIS) as neo-adjuvant chemotherapy for locally-advanced squamous cervical carcinoma: Results of a phase II multicentric study

European journal of cancer (Oxford, England : 1990) · Mar 2013 · Phase II multicenter, single-arm neoadjuvant chemotherapy trial

TopotecanCisplatinsquamous cervical carcinomaadenosquamous cervical carcinomalocally-advanced cervical cancer (FIGO IB2, IIA, IIB)

This phase II multicenter study enrolled 92 patients with locally advanced squamous or adenosquamous cervical cancer who received six weekly courses of topotecan (2 mg/m2) plus cisplatin (40 mg/m2) as neoadjuvant chemotherapy. The regimen was deliverable (96% completed six courses; 95% of courses given at full dose) and produced a clinical response rate of 77% and an overall pathologic response in 67% (optimal response 32%, downstaging 57%). Grade 3-4 hematologic toxicity occurred in 28% of patients, supportive therapies were given to 24%, and with median follow-up 18 months, 76% were alive and recurrence-free while 24% relapsed and 13% died.

Reported effects: treatment_completion 96%, n=92 · full_dose_course_percentage 95%, n=92 · +13 more

Studied with: cisplatin.

Key findings
  • 96% of patients completed the six planned courses of chemotherapy.
  • 95% of courses were administered at a full dose and without interruption or delay.
  • Grade 3-4 haematological toxicity was observed in 28% of patients (5% out of cycles).
  • Support therapies were given to 24% of patients.
  • Clinical response rate was 77%.
  • Overall pathologic response observed in 67% of patients.
  • Optimal pathologic response rate was 32%.
  • Disease downstage occurred in 57% of patients.
  • Nodal metastases occurred in 36% of patients.
  • Adjuvant radiotherapy and/or chemotherapy was prescribed in 55% of patients.
  • Median follow-up was 18 months; 76% alive and free from recurrence, 24% relapsed, 13% died.
Limitations: Single-arm Phase II design with no randomized or concurrent control group; Relatively short median follow-up (18 months) for survival outcomes; Adjuvant therapy was given to 55% of patients, which may confound interpretation of longer-term outcomes; Sample size (n=92) limits precision of survival and subgroup estimates; Endpoints are primarily response and short-term outcomes rather than long-term randomized efficacy.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

Meta-analysisTrialInconclusiveLimited evidenceTier 4 · clinical

Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma

The Cochrane database of systematic reviews · Feb 2013 · Cochrane systematic review of randomized controlled trials (searched for RCTs) and discussion of non-randomised studies; search up to February 2012

CyclophosphamideTaxolCisplatinDacarbazineIfosfamideDoxorubicinovarian carcinosarcoma

This Cochrane systematic review searched for randomized trials comparing neoadjuvant or adjuvant chemotherapy and radiotherapy, or chemotherapy alone, combined with surgery for ovarian carcinosarcoma and found no eligible randomized controlled trials. The authors therefore found no evidence to inform decisions about which adjuvant or neoadjuvant regimens to use and called for multicentre RCTs or well-designed non-randomised studies and further molecular research.

Studied with: surgery, radiotherapy, chemotherapy.

Key findings
  • No randomized controlled trials were identified comparing neoadjuvant or adjuvant chemotherapy and radiotherapy, or chemotherapy alone, in women with ovarian carcinosarcoma.
  • The search strategy identified 297 unique references, all of which were excluded and therefore no data were analysed.
  • Various chemotherapy regimens have been used historically (including cisplatin; combinations with doxorubicin, ifosfamide, dacarbazine, cyclophosphamide, taxol), but their effectiveness appears mixed.
  • Authors recommend multicentre or multinational RCTs, or well-designed non-randomised studies using multivariate analysis, and further research into genetic and molecular signalling pathways.
  • The authors note the importance of addressing quality of life and toxicity given the generally poor prognosis.
Limitations: No randomized controlled trials were found, so no quantitative data or pooled analysis could be performed.; Search was conducted up to February 2012; more recent studies (after that date) would not be included.; Rare disease with likely limited available studies, limiting the ability to draw conclusions..

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed · Full text

ReviewMixed resultsModerate evidenceTier 4 · clinical

Therapeutic strategies in epithelial ovarian cancer

Journal of experimental & clinical cancer research : CR · Feb 2012 · review

BevacizumabCisplatinepithelial ovarian cancerprimary peritoneal carcinomaclear cell adenocarcinoma (ovarian)serous adenocarcinoma (ovarian)

This review summarizes current therapeutic approaches for epithelial ovarian cancer, noting standard treatment is cytoreductive surgery plus taxane-and-platinum chemotherapy. It highlights that many apparent primary ovarian carcinomas may arise from the fimbria, that clear cell histology is relatively chemoresistant to carboplatin/paclitaxel and may respond to irinotecan plus cisplatin, and that targeted agents such as bevacizumab and PARP inhibitors are promising with some studies showing improved progression-free survival for bevacizumab.

Studied with: paclitaxel + platinum, irinotecan + cisplatin, bevacizumab (with chemotherapy).

Key findings
  • Epithelial ovarian cancer is the most lethal gynecologic malignancy.
  • Many tumors thought to be primary ovarian or peritoneal carcinomas may originate from the fimbria of the fallopian tube.
  • Standard treatment is cytoreductive surgery plus combination chemotherapy using taxane and platinum.
  • Clear cell ovarian carcinoma shows relative resistance to carboplatin and paclitaxel and therefore has poorer prognosis compared with serous adenocarcinoma in advanced stages.
  • Irinotecan plus cisplatin therapy may be effective for clear cell adenocarcinoma.
  • Bevacizumab (anti-VEGF) and PARP inhibitors are promising molecular targeted drugs in ovarian cancer.
  • A few recent studies demonstrated positive results of bevacizumab on progression-free survival, but investigations of molecular targeted drugs in ovarian cancer are still underway.
Limitations: This publication is a review and does not present new primary data.; The abstract cites only 'a few recent studies' for bevacizumab, indicating limited summarized evidence in this text.; No quantitative results, sample sizes, or detailed trial designs are provided in the abstract.; Statements about efficacy for specific subtypes (e.g., clear cell) are not supported by detailed outcome data in the abstract..

Overview of therapeutic strategies and emerging targeted therapies for epithelial ovarian cancer.

AI summary of the abstract, human-reviewed · Jul 2026. Describes what this study reported, not medical advice. View on PubMed · Full text

Case reportReported negativeLimited evidenceTier 3 · early humann = 1

Prostate small cell carcinoma and skin metastases: a rare entity

Medical principles and practice : international journal of the Kuwait University, Health Science Centre · Jan 2008 · case_report

CisplatinEtoposideprostate small cell carcinomaprostate adenocarcinoma (component)skin metastasis (scrotal)

This is a case report of a 60-year-old man diagnosed with small cell carcinoma of the prostate (with adenocarcinoma component) who received combination chemotherapy with cisplatin and etoposide and bilateral orchiectomy. Disease progressed after six cycles, he did not respond to salvage therapy, and later developed scrotal skin papillary lesions that on biopsy were metastatic small cell carcinoma. The authors note that prostate small cell carcinoma is aggressive with high metastatic potential but skin metastases are uncommon and prognosis is poor despite therapy.

Studied with: bilateral orchiectomy.

Key findings
  • Needle biopsy showed both small cell carcinoma and adenocarcinoma of the prostate.
  • Patient was treated with combination chemotherapy (cisplatin and etoposide) and bilateral orchiectomy.
  • After six cycles of chemotherapy, disease progressed and the patient did not respond to salvage therapy; palliative care was instituted.
  • During follow-up, papillary lesions on scrotal skin were biopsied and shown to be metastatic small cell carcinoma.
  • Authors state small cell carcinoma of the prostate is aggressive with high metastatic potential and poor prognosis; skin metastases are very uncommon.
Limitations: Single-patient case report; findings not generalizable.; No control or comparator.; No chemotherapy dosing or detailed treatment timelines provided.; Limited clinical detail and follow-up reported.; Cannot determine treatment efficacy from a single case and no quantitative outcomes reported..

Reports clinical course and an uncommon site of metastasis (skin) in prostate small cell carcinoma, relevant to clinicians encountering aggressive prostatic neuroendocrine tumors.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

Human · observationalInconclusiveLimited evidenceTier 3 · early humann = 22

Carcinosarcoma of the ovary

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · Jan 2008 · retrospective registry review

CarboplatinTaxolCisplatinIfosfamideovarian carcinosarcoma

This retrospective study reviewed 22 women with ovarian carcinosarcoma treated at one institution. Most patients had advanced disease, and the authors reported median survival and progression-free intervals for different surgery and chemotherapy groups. Survival was not significantly different between the cisplatin/ifosfamide group and the carboplatin/taxol group. The study suggests these regimens were used in this rare cancer, but it does not establish which one is better.

Reported effects: median survival for the entire cohort 38 mo, n=22 · median survival for 18 optimally debulked (<1 cm) patients 46 mo, n=18 · +3 more

Studied with: ifosfamide, taxol, carboplatin, cisplatin.

Key findings
  • Twenty-two patients were identified, and all but two presented with advanced stage disease.
  • Median survival for the entire cohort was 38 months.
  • Median survival was 46 months for optimally debulked patients and 27 months for suboptimally debulked patients.
  • In the cisplatin and ifosfamide group, median progression-free interval was 13 months and median survival was 51 months.
  • In the carboplatin and taxol group, median progression-free interval was 6 months and median survival was 38 months.
  • The difference in survival between the two chemotherapy groups was not statistically significant (P=0.48).
Limitations: Retrospective single-institution review; Small sample size; No randomized control group; Non-comparative treatment groups with likely selection bias; Rare cancer with limited generalizability; Survival differences were not statistically significant.

This is an observational outcomes study in ovarian carcinosarcoma evaluating surgery and chemotherapy regimens.

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

Animal studyReported positivePreclinical onlyTier 2 · animal

Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents

Biochimica et biophysica acta · Dec 2003

DoxorubicinCisplatinovarian sarcoma (M5076)

In mice bearing M5076 ovarian sarcoma, co-administration of theanine increased tumor doxorubicin concentration, enhanced the antitumor activity of doxorubicin and suppressed hepatic metastasis, while not increasing doxorubicin levels in normal tissues or worsening markers of doxorubicin-induced toxicity. In vitro, theanine inhibited glutamate uptake and doxorubicin efflux from tumor cells, reduced intracellular glutamate, GSH and GS-DOX conjugate levels, and the authors propose involvement of MRP5/GS-X export; similar effects were seen with specific glutamate transporter inhibitors and with other chemotherapeutics.

Studied with: doxorubicin, other anthracyclines, cisplatin, irinotecan, green tea (oral).

Key findings
  • In M5076 ovarian sarcoma-bearing mice, theanine significantly enhanced the inhibitory effect of DOX on tumor growth and increased the DOX concentration in the tumor, compared to DOX-alone group.
  • Oral administration of theanine or green tea similarly enhanced the antitumor activity of DOX.
  • The combination of theanine with DOX suppressed the hepatic metastasis of ovarian sarcoma.
  • An increase in DOX concentration was not observed in normal tissues such as liver and heart, and theanine tended to normalize DOX-induced increases in lipid peroxide levels and reduction of glutathione peroxidase activity.
  • In vitro, theanine inhibited the efflux of DOX from tumor cells and significantly inhibited glutamate uptake by M5076 cells similar to specific inhibitors.
  • Two astrocytic high-affinity glutamate transporters, GLAST and GLT-1, were expressed in M5076 cells.
  • Theanine-induced reduction of intracellular glutamate caused decreases in intracellular glutathione (GSH) and GS-DOX conjugate levels; expression of MRP5 suggests export of GS-DOX via the MRP5/GS-X pump, which theanine affected.
  • DHK and L-serine-O-sulfate (SOS), specific glutamate transporter inhibitors, also enhanced DOX antitumor activity via inhibition of glutamate uptake.
  • Theanine enhanced the antitumor activities of other anthracyclines, cisplatin and irinotecan in this experimental context.
Limitations: Preclinical study in a single mouse tumor model and in vitro cell line; no human data reported.; Abstract does not report sample sizes, dosing regimens, or duration of treatment.; Safety and efficacy in humans are not evaluated; applicability to clinical chemotherapy is speculative.; Mechanistic links are inferred from in vitro findings and expression data rather than directly proven in patients..

AI summary of the abstract, human-reviewed · Jun 2026. Describes what this study reported, not medical advice. View on PubMed

What changed recently

The latest additions to Cisplatin's evidence base, and anything that's been retracted.

Recently added

Cancers where Cisplatin reported positive results

Where at least one study reported a positive result, shown with the full picture, not just the wins. Positive results are more likely to be published, and most of these are early lab or animal studies that may not translate to people. This reports what studies found, not what works.

Human evidence

Epithelial ovarian cancer1 positive1 negative/mixed1 human
Limitations: Open-label design (no blinding).; Increased perioperative grade 3+ toxicity with HIPEC compared with no HIPEC.; Eligibility limited to patients with a first relapse ≥6 months after platinum-based chemotherapy who were amenable to complete cytoreduction; results may not generalise to other patient groups.; Optional use of bevacizumab and later planned PARP inhibitor use introduce heterogeneity in systemic therapy.; Conducted at specialist centres; generalisability to non-specialist settings is uncertain..
Cited positive studies (1)
Recurrent ovarian cancer1 positive1 human
Limitations: Open-label design (no blinding).; Increased perioperative grade 3+ toxicity with HIPEC compared with no HIPEC.; Eligibility limited to patients with a first relapse ≥6 months after platinum-based chemotherapy who were amenable to complete cytoreduction; results may not generalise to other patient groups.; Optional use of bevacizumab and later planned PARP inhibitor use introduce heterogeneity in systemic therapy.; Conducted at specialist centres; generalisability to non-specialist settings is uncertain..
Cited positive studies (1)
High-grade serous ovarian cancer1 positive1 human
Limitations: Open-label design (no blinding).; Increased perioperative grade 3+ toxicity with HIPEC compared with no HIPEC.; Eligibility limited to patients with a first relapse ≥6 months after platinum-based chemotherapy who were amenable to complete cytoreduction; results may not generalise to other patient groups.; Optional use of bevacizumab and later planned PARP inhibitor use introduce heterogeneity in systemic therapy.; Conducted at specialist centres; generalisability to non-specialist settings is uncertain..
Cited positive studies (1)
High-grade endometrioid ovarian cancer1 positive1 human
Limitations: Open-label design (no blinding).; Increased perioperative grade 3+ toxicity with HIPEC compared with no HIPEC.; Eligibility limited to patients with a first relapse ≥6 months after platinum-based chemotherapy who were amenable to complete cytoreduction; results may not generalise to other patient groups.; Optional use of bevacizumab and later planned PARP inhibitor use introduce heterogeneity in systemic therapy.; Conducted at specialist centres; generalisability to non-specialist settings is uncertain..
Cited positive studies (1)
Uterine leiomyosarcoma1 positive1 human
Limitations: Small number of HRD cases (5 of 58), with only three patients having mature clinical follow-up.; Non-randomized, observational access to PARPi in patients (no control arm reported).; PDX (preclinical) findings may not fully predict clinical efficacy.; Sequencing methods varied across samples (WGS, WES, panel), and some genomic HRD metrics (CHORD) were discordant.; No dosing, schedule, or detailed treatment-response durations provided in the abstract..
Cited positive studies (1)
Squamous cervical carcinoma1 positive1 human
Limitations: Single-arm Phase II design with no randomized or concurrent control group; Relatively short median follow-up (18 months) for survival outcomes; Adjuvant therapy was given to 55% of patients, which may confound interpretation of longer-term outcomes; Sample size (n=92) limits precision of survival and subgroup estimates; Endpoints are primarily response and short-term outcomes rather than long-term randomized efficacy.
Cited positive studies (1)
Adenosquamous cervical carcinoma1 positive1 human
Limitations: Single-arm Phase II design with no randomized or concurrent control group; Relatively short median follow-up (18 months) for survival outcomes; Adjuvant therapy was given to 55% of patients, which may confound interpretation of longer-term outcomes; Sample size (n=92) limits precision of survival and subgroup estimates; Endpoints are primarily response and short-term outcomes rather than long-term randomized efficacy.
Cited positive studies (1)
Locally-advanced cervical cancer (FIGO IB2, IIA, IIB)1 positive1 human
Limitations: Single-arm Phase II design with no randomized or concurrent control group; Relatively short median follow-up (18 months) for survival outcomes; Adjuvant therapy was given to 55% of patients, which may confound interpretation of longer-term outcomes; Sample size (n=92) limits precision of survival and subgroup estimates; Endpoints are primarily response and short-term outcomes rather than long-term randomized efficacy.
Cited positive studies (1)
Preclinical only: lab / animal (3)
Mixed germ cell tumor of fallopian tube1 positive
Limitations: Single-patient case report — no control group and limited generalizability.; No dosing amounts/administration details for chemotherapy provided in the abstract.; Follow-up limited to 24 months as reported; longer-term outcomes beyond that are not reported in the abstract.; Outcomes from a single case cannot establish efficacy or safety of the treatment..
Cited positive studies (1)
Limitations: Single-patient case report — no control group and limited generalizability.; No dosing amounts/administration details for chemotherapy provided in the abstract.; Follow-up limited to 24 months as reported; longer-term outcomes beyond that are not reported in the abstract.; Outcomes from a single case cannot establish efficacy or safety of the treatment..
Cited positive studies (1)
Ovarian sarcoma (M5076)1 positive1 animal
Limitations: Preclinical study in a single mouse tumor model and in vitro cell line; no human data reported.; Abstract does not report sample sizes, dosing regimens, or duration of treatment.; Safety and efficacy in humans are not evaluated; applicability to clinical chemotherapy is speculative.; Mechanistic links are inferred from in vitro findings and expression data rather than directly proven in patients..
Cited positive studies (1)

Evidence at a glance: Cisplatin by cancer

A deterministic grade of what published studies report for each: strength of evidence, the reported direction, and the largest credible effect, strongest-evidence first. This summarizes findings; it is not a claim that anything works.

Epithelial ovarian cancerHuman trial / meta-analysisMixed results1 human

Includes human trial or meta-analysis evidence.

Largest credible effect: stratified hazard ratio for overall survival 0.73 [0.56–0.96], p=0.024, n=415 PMID 39549720 · response rates 10–49 across 5 studies

Most authoritative study: Hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer (CHIPOR): a randomised, open-label, phase 3 trial

Findings conflict across studies · Effect sizes reported in only 1 of 2 studies.
Ovarian carcinosarcomaHuman trial / meta-analysisInconclusive2 human

Includes human trial or meta-analysis evidence.

Largest credible effect: median survival for the entire cohort 38 mo, n=22 PMID 17451459 · median-survival values 27–51 across 5 studies

Most authoritative study: Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma

Effect sizes reported in only 1 of 2 studies.
Adenosquamous cervical carcinomaHuman trial / meta-analysisReported positive1 human

Includes human trial or meta-analysis evidence.

Largest credible effect: treatment_completion 96%, n=92 PMID 23151423 · response rates 13–77 across 9 studies

Most authoritative study: Weekly topotecan and cisplatin (TOPOCIS) as neo-adjuvant chemotherapy for locally-advanced squamous cervical carcinoma: Results of a phase II multicentric study

Based on a single study.
High-grade endometrioid ovarian cancerHuman trial / meta-analysisReported positive1 human

Includes human trial or meta-analysis evidence.

Largest credible effect: stratified hazard ratio for overall survival 0.73 [0.56–0.96], p=0.024, n=415 PMID 39549720 · response rates 10–49 across 5 studies

Most authoritative study: Hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer (CHIPOR): a randomised, open-label, phase 3 trial

Based on a single study.
High-grade serous ovarian cancerHuman trial / meta-analysisReported positive1 human

Includes human trial or meta-analysis evidence.

Largest credible effect: stratified hazard ratio for overall survival 0.73 [0.56–0.96], p=0.024, n=415 PMID 39549720 · response rates 10–49 across 5 studies

Most authoritative study: Hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer (CHIPOR): a randomised, open-label, phase 3 trial

Based on a single study.
Locally-advanced cervical cancer (FIGO IB2, IIA, IIB)Human trial / meta-analysisReported positive1 human

Includes human trial or meta-analysis evidence.

Largest credible effect: treatment_completion 96%, n=92 PMID 23151423 · response rates 13–77 across 9 studies

Most authoritative study: Weekly topotecan and cisplatin (TOPOCIS) as neo-adjuvant chemotherapy for locally-advanced squamous cervical carcinoma: Results of a phase II multicentric study

Based on a single study.
Recurrent ovarian cancerHuman trial / meta-analysisReported positive1 human

Includes human trial or meta-analysis evidence.

Largest credible effect: stratified hazard ratio for overall survival 0.73 [0.56–0.96], p=0.024, n=415 PMID 39549720 · response rates 10–49 across 5 studies

Most authoritative study: Hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer (CHIPOR): a randomised, open-label, phase 3 trial

Based on a single study.
Squamous cervical carcinomaHuman trial / meta-analysisReported positive1 human

Includes human trial or meta-analysis evidence.

Largest credible effect: treatment_completion 96%, n=92 PMID 23151423 · response rates 13–77 across 9 studies

Most authoritative study: Weekly topotecan and cisplatin (TOPOCIS) as neo-adjuvant chemotherapy for locally-advanced squamous cervical carcinoma: Results of a phase II multicentric study

Based on a single study.
Cervical squamous carcinomaHuman · observationalReported negative1 human

Human observational evidence only — no trials.

Largest credible effect: clinical response 48.6%, n=35 PMID 31470801 · response rates 14.3–48.6 across 3 studies

Most authoritative study: Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT

Based on a single study.
Uterine leiomyosarcomaHuman · observationalReported positive1 human

Human observational evidence only — no trials.

Largest credible effect: Individuals with HRD uLMS in the screened cohort 9%, n=58 PMID 37143137 · effect sizes 2–13 across 4 studies

Most authoritative study: Targeting homologous recombination deficiency in uterine leiomyosarcoma

Based on a single study.
Ovarian sarcoma (M5076)Animal onlyReported positive1 animal

Animal studies only — no human data.

Most authoritative study: Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents

No human studies yet · No numeric effect sizes reported · Based on a single study.
Advanced or metastatic high-grade epithelial ovarian cancerInsufficient evidenceInconclusive

No primary experimental studies yet.

Most authoritative study: Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer

No human studies yet · No numeric effect sizes reported · Based on a single study.
Clear cell adenocarcinoma (ovarian)Insufficient evidenceMixed results

No primary experimental studies yet.

Most authoritative study: Therapeutic strategies in epithelial ovarian cancer

No human studies yet · No numeric effect sizes reported · Based on a single study.
High-grade epithelial ovarian cancerInsufficient evidenceInconclusive

No primary experimental studies yet.

Most authoritative study: Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer

No human studies yet · No numeric effect sizes reported · Based on a single study.
Lung cancerInsufficient evidenceMixed results

No primary experimental studies yet.

Most authoritative study: Platinum-based targeted chemotherapies and reversal of cisplatin resistance in non-small cell lung cancer (NSCLC)

No human studies yet · No numeric effect sizes reported · Based on a single study.
Mixed germ cell tumor of fallopian tubeInsufficient evidenceReported positive

No primary experimental studies yet.

Largest credible effect: tumor_free_survival 24 mo, n=1 PMID 37660086

Most authoritative study: Malignant germ cell tumor of fallopian tube with rhabdomyosarcoma: a case report and literature review

No human studies yet · Based on a single study.
Non-small-cell lung cancerInsufficient evidenceMixed results

No primary experimental studies yet.

Most authoritative study: Platinum-based targeted chemotherapies and reversal of cisplatin resistance in non-small cell lung cancer (NSCLC)

No human studies yet · No numeric effect sizes reported · Based on a single study.
NSCLCInsufficient evidenceMixed results

No primary experimental studies yet.

Most authoritative study: Platinum-based targeted chemotherapies and reversal of cisplatin resistance in non-small cell lung cancer (NSCLC)

No human studies yet · No numeric effect sizes reported · Based on a single study.
Ovarian epithelial carcinomaInsufficient evidenceInconclusive

No primary experimental studies yet.

Most authoritative study: Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer

No human studies yet · No numeric effect sizes reported · Based on a single study.
Primary peritoneal carcinomaInsufficient evidenceMixed results

No primary experimental studies yet.

Most authoritative study: Therapeutic strategies in epithelial ovarian cancer

No human studies yet · No numeric effect sizes reported · Based on a single study.
Prostate adenocarcinoma (component)Insufficient evidenceReported negative

No primary experimental studies yet.

Most authoritative study: Prostate small cell carcinoma and skin metastases: a rare entity

No human studies yet · No numeric effect sizes reported · Based on a single study.
Prostate small cell carcinomaInsufficient evidenceReported negative

No primary experimental studies yet.

Most authoritative study: Prostate small cell carcinoma and skin metastases: a rare entity

No human studies yet · No numeric effect sizes reported · Based on a single study.
RhabdomyosarcomaInsufficient evidenceReported positive

No primary experimental studies yet.

Largest credible effect: tumor_free_survival 24 mo, n=1 PMID 37660086

Most authoritative study: Malignant germ cell tumor of fallopian tube with rhabdomyosarcoma: a case report and literature review

No human studies yet · Based on a single study.
Serous adenocarcinoma (ovarian)Insufficient evidenceMixed results

No primary experimental studies yet.

Most authoritative study: Therapeutic strategies in epithelial ovarian cancer

No human studies yet · No numeric effect sizes reported · Based on a single study.

Dose: as studied, not a recommendation

These are doses as studied or reported, never a recommendation. The right amount of Cisplatin depends on you, your other medicines, and your situation; decide it with your oncology team and pharmacist, not from a web page.
Doses reported in studies

Clinical trials studying Cisplatin

23 ongoing · 63 completed · tracked from ClinicalTrials.gov. Recruiting is not the same as proven, and completed is not the same as positive — read the results. Not a recommendation.

Completed
15 stopped (terminated / withdrawn / suspended)

Search all trials on ClinicalTrials.gov →

Inclusion here is not an endorsement. OncoForge makes no claim beyond what the linked studies show. Discuss anything on this page with your oncology team before acting on it.

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