Reported positive (1)
- Targeting PD-L1 for non-small-cell lung cancer
Review · Moderate evidence · Jun 2016
Rx ICI: PD-1 ↓ → T-cell ↑; OS/PFS across melanoma/NSCLC/RCC/HNSCC/MSI-high; irAE management key.
Human trial / meta-analysis — Includes human trial or meta-analysis evidence.
Computed deterministically from the studies’ types and reported outcomes — not written by AI, and not a claim that anything works.
Forms: IV infusion (10 mg/mL concentrate) · Prefilled syringes (100 mg/10 mL, 240 mg/24 mL)
Anti–PD-1 checkpoint inhibitor that restores exhausted T cells and delivers survival gains across multiple cancers (melanoma, NSCLC, RCC, HNSCC, others); requires vigilant monitoring for immune-related toxicities.
20+ phase III approvals; OS HR 0.6-0.8 in frontline; durable 5y OS 30-50% in melanoma/NSCLC; meta-combination benefits with CTLA-4i/chemo; ongoing in adjuvant/metastatic.
By binding PD-1 on T cells, nivolumab prevents engagement with PD-L1/PD-L2, reversing T-cell exhaustion and boosting cytotoxic activity and memory responses. Tumor control stems from renewed CD8⁺ infiltration and effector function. Durable response ‘tails’ on survival curves occur in subsets with immunogenic tumors or high neoantigen burden.
Curated mechanistic targets reported for this agent — how it may act on cells, not proof of a clinical effect.
Combinations reported in the literature, not a protocol or a recommendation.
Severity and how well-established each signal is are shown separately. Verify everything with your oncologist or pharmacist — absence here does not mean safe.
What has been studied, and how strong it is, by topic. A dashed cell means no studies were found for that combination — a gap, not evidence of no effect. Open a row to see its studies.
4 published studies by what they were done in. Lab and animal findings often do not carry over to people.
The kinds of sources behind this page, strongest at the top. Faint rungs show what is not here yet.
Tracking 4 published studies of Nivolumab †Rx: 1 in humans, 3 reviews/other.
Reported direction across studies: 1 positive, 1 mixed, 2 inconclusive.
Findings conflict — both supportive and negative/mixed results exist (see below). Human evidence is limited.
These counts summarize what the studies reported; they are not a measure of whether Nivolumab †Rx works.
Cancers named in these studies
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · Dec 2021 · Randomized, double-blind, phase III, international, multicenter; two independent comparisons (ATHENA-MONO and ATHENA-COMBO) with 4:4:1:1 randomization
This report describes ATHENA, a randomized, double-blind phase III trial testing rucaparib as frontline maintenance versus placebo (ATHENA-MONO) and rucaparib plus nivolumab versus rucaparib alone (ATHENA-COMBO) in women with newly diagnosed ovarian, fallopian tube, or peritoneal cancer who responded to platinum-based chemotherapy. About 1000 patients were randomized into four arms (rucaparib+nivolumab; rucaparib+placebo; placebo+nivolumab; placebo+placebo); the primary endpoint is investigator-assessed progression-free survival. The trial completed accrual in 2020 and primary results for ATHENA-MONO were anticipated in early 2022; no outcome data are reported in this abstract.
Studied with: nivolumab.
AI summary of the abstract, human-reviewed · Jul 2026. Describes what this study reported, not medical advice. View on PubMed · Full text
Clinical nuclear medicine · Sep 2020 · case report
This is a single-patient case report of a 39-year-old woman whose F-FDG PET/CT showed high uptake in a tumor in the pouch of Douglas and in metastatic sites; biopsy confirmed mesonephric carcinoma with metastases. She received six cycles of carboplatin, paclitaxel, and bevacizumab without sufficient response, after which checkpoint immunotherapy with nivolumab and ipilimumab was started.
Studied with: carboplatin + paclitaxel + bevacizumab, nivolumab + ipilimumab.
Documents FDG-PET/CT avidity of metastatic mesonephric carcinoma and reports prior chemotherapy failure with subsequent initiation of combination checkpoint immunotherapy.
AI summary of the abstract, human-reviewed · Aug 2026. Describes what this study reported, not medical advice. View on PubMed
Gynecologic oncology · Dec 2018 · literature review
This is a literature review of uterine leiomyosarcoma covering epidemiology, presentation, diagnosis, pathology, and management. The authors state that early-stage management is surgical (hysterectomy) and that routine oophorectomy or lymph node dissection appear to provide little benefit; adjuvant therapy remains controversial with trials failing to show overall survival benefit. They note recent progress in advanced/recurrent disease with novel chemotherapeutics, targeted agents (olaratumab, pazopanib) and immune checkpoint inhibitors (nivolumab, pembrolizumab) showing promise.
AI summary of the abstract, human-reviewed · Jul 2026. Describes what this study reported, not medical advice. View on PubMed
Immunotherapy · Jun 2016
This is a review of PD-1 and PD-L1 immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC). The abstract states that anti-PD-1 antibodies nivolumab and pembrolizumab are FDA-approved for NSCLC and other tumor types, and that additional agents targeting this pathway are in clinical development. The review summarizes updates on these agents being evaluated in NSCLC patients.
AI summary of the abstract, human-reviewed · Jul 2026. Describes what this study reported, not medical advice. View on PubMed
The latest additions to Nivolumab †Rx's evidence base, and anything that's been retracted.
Recently addedWhere at least one study reported a positive result, shown with the full picture, not just the wins. Positive results are more likely to be published, and most of these are early lab or animal studies that may not translate to people. This reports what studies found, not what works.
A deterministic grade of what published studies report for each: strength of evidence, the reported direction, and the largest credible effect, strongest-evidence first. This summarizes findings; it is not a claim that anything works.
Includes human trial or meta-analysis evidence.
Includes human trial or meta-analysis evidence.
Includes human trial or meta-analysis evidence.
Includes human trial or meta-analysis evidence.
No primary experimental studies yet.
Most authoritative study: 18F-FDG Uptake in a Mesonephric Carcinoma
No primary experimental studies yet.
Most authoritative study: Targeting PD-L1 for non-small-cell lung cancer
No primary experimental studies yet.
Most authoritative study: Uterine leiomyosarcoma: A review of the literature and update on management options
Ranges seen in adjunct / practice use: 240–480 mg IV q2-4w (IV) Flat dose: 240 mg q2w or 480 mg q4w; weight-based alternatives, Most tumors 240 mg q2w; melanoma/RCC 480 mg q4w; infuse over 30 min; premed not required..
Doses reported in studies48 ongoing · 36 completed · tracked from ClinicalTrials.gov. Recruiting is not the same as proven, and completed is not the same as positive — read the results. Not a recommendation.